颈椎后纵韧带骨化症患者颈椎前路精准后纵韧带骨化块整体切除与分块切除的临床疗效及安全性比较研究:倾向评分匹配分析

A comparative study on clinical outcomes and safety of accurate anterior cervical ossified posterior longitudinal ligament en bloc resection versus piecemeal resection in patients with ossification of the cervical posterior longitudinal ligament: a propensity score-matching analysis.

作者信息

Chen Kefu, Zhang Hao, Lu Yiwei, Zhang Jian, Liu Xiaodong, Jia Lianshun, Dong Xingcheng, Chen Xiongsheng

机构信息

Shanghai Changhai Hospital, Shanghai, China.

Naval Medical Center of Chinese People's Liberation Army, Shanghai, China.

出版信息

BMC Musculoskelet Disord. 2025 Apr 17;26(1):377. doi: 10.1186/s12891-025-08624-w.

Abstract

OBJECTIVE

The anterior approach for cervical ossification of posterior longitudinal ligament (OPLL) excision can improve long-term neurofunctional recovery by providing direct spinal cord decompression. The objective of the present study was to compare the clinical outcomes and complications between accurate anterior cervical ossified posterior longitudinal ligament en bloc resection (ACOE) versus piecemeal resection (ACOP) using propensity score-matching analysis.

METHODS

Included in this study were 189 OPLL patients (65 female) who underwent anterior cervical surgery, with a mean age of 54.85 years. Of them, 105 patients (39 female) with a mean age of 55.69 years underwent ACOE, and the remaining 84 patients (26 female) with a mean age of 53.80 underwent ACOP. Of the 189 patients, 70 patients (37%) had a canal occupying ratio (COR) ≥ 50%, and therefore the patient data were stratified by COR with 50%. The clinical outcomes were compared between the two groups during a at least 27-month follow-up period.

RESULTS

The mean final follow-up JOA score in ACOE group was higher than that in ACOP group. The JOA recovery rate of patients with COR ≥ 50% was higher in ACOE group. The mean operative time and intraoperative blood loss were both lower in ACOE group. However, postoperative complications were not significantly different between the two groups.

CONCLUSION

This study demonstrated that the ACOE technique gained higher JOA recovery rates and better neurological recovery than ACOP for OPLL patients with COR ≥ 50%. In addition, ACOE offered a shorter operative time and less intraoperative blood loss as compared with ACOP. Therefore, the postoperative complications were not more common between two groups.

摘要

目的

颈椎后纵韧带骨化症(OPLL)切除的前路手术可通过直接减压脊髓来改善长期神经功能恢复。本研究的目的是采用倾向得分匹配分析比较精确颈椎后纵韧带骨化块全切除(ACOE)与分块切除(ACOP)的临床疗效和并发症。

方法

本研究纳入189例行颈椎前路手术的OPLL患者(65例女性),平均年龄54.85岁。其中,105例患者(39例女性)平均年龄55.69岁接受了ACOE,其余84例患者(26例女性)平均年龄53.80岁接受了ACOP。在189例患者中,70例患者(37%)的椎管占位率(COR)≥50%,因此将患者数据按COR 50%进行分层。在至少27个月的随访期内比较两组的临床疗效。

结果

ACOE组末次随访时的平均JOA评分高于ACOP组。COR≥50%的患者中,ACOE组的JOA恢复率更高。ACOE组的平均手术时间和术中出血量均较低。然而,两组术后并发症无显著差异。

结论

本研究表明,对于COR≥50%的OPLL患者,ACOE技术比ACOP获得更高的JOA恢复率和更好的神经功能恢复。此外,与ACOP相比,ACOE手术时间更短,术中出血量更少。因此,两组术后并发症并不更常见。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16ed/12004819/cf254a209c46/12891_2025_8624_Fig1_HTML.jpg

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