庆大霉素对雄性和雌性大鼠离体灌注肾脏肾功能的影响。

Effects of gentamicin on renal function in isolated perfused kidneys from male and female rats.

作者信息

Miura K, Pasino D A, Goldstein R S, Hook J B

出版信息

Toxicol Lett. 1985 Jul;26(1):15-8. doi: 10.1016/0378-4274(85)90178-x.

Abstract

The isolated perfused rat kidney was used to determine whether sex differences in gentamicin nephrotoxicity are related to intrinsic differences in renal response to gentamicin. Acute exposure to gentamicin decreased fractional reabsorption of water and electrolytes without changes in glomerular filtration rate in both sexes. Gentamicin decreased the tubular reabsorption of lysozyme but not glomerular permeability to lysozyme. No sex differences in renal responses were observed following in vitro exposures to gentamicin, suggesting that sex differences in susceptibility to gentamicin in vivo may be attributable to extrarenal factors, such as pharmacokinetics.

摘要

采用离体灌流大鼠肾脏来确定庆大霉素肾毒性的性别差异是否与肾脏对庆大霉素反应的内在差异有关。急性暴露于庆大霉素后，两性的水和电解质重吸收分数均降低，而肾小球滤过率无变化。庆大霉素降低了溶菌酶的肾小管重吸收，但未改变肾小球对溶菌酶的通透性。体外暴露于庆大霉素后未观察到肾脏反应的性别差异，这表明体内对庆大霉素易感性的性别差异可能归因于肾外因素，如药代动力学。