Bacterial infections markedly strain healthcare systems financially, compounded by the rise of drug-resistant strains and biofilm-associated infections. Gas therapy has emerged as a notable solution, disrupting biofilms and targeting resistant bacteria through controlled gas release mechanisms. However, achieving precise and controlled gas release remains a critical challenge for the successful implementation of gas therapy. In this perspective, we summarize recent advancements in photocatalytic gas release for treating bacterial infections. It also outlines crucial challenges that must be addressed to fully leverage this promising therapeutic strategy, enhancing its precision and effectiveness in clinical settings.