Department of Surgery-Transplant and Mary & Dick Holland Regenerative Medicine Program, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Department of Emergency Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Microb Biotechnol. 2024 Oct;17(10):e70035. doi: 10.1111/1751-7915.70035.
Bacterial infections represent a significant global threat to human health, leading to considerable economic losses through increased healthcare costs and reduced productivity. One major challenge in treating these infections is the presence of biofilms - structured bacterial communities that form protective barriers, making traditional treatments less effective. Additionally, the rise of antibiotic-resistant bacteria has exacerbated treatment difficulties. To address these challenges, researchers are developing and exploring innovative approaches to combat biofilm-related infections. This mini-review highlights recent advancements in the following key areas: surface anti-adhesion technologies, electricity, photo/acoustic-active materials, endogenous mimicking agents, and innovative drug delivery systems. These strategies aim to prevent biofilm formation, disrupt existing biofilms, and enhance the efficacy of antimicrobial treatments. Currently, these approaches show great potential for applications in medical fields such as medical device and wound - associated biofilm infections. By summarizing these developments, this mini-review provides a comprehensive resource for researchers seeking to advance the management and treatment of biofilm-associated infections.
细菌感染对人类健康构成重大全球威胁，导致医疗成本增加和生产力下降，从而造成巨大的经济损失。治疗这些感染的一个主要挑战是生物膜的存在 - 形成保护性屏障的结构化细菌群落，使传统治疗方法效果降低。此外，抗生素耐药菌的出现使治疗变得更加困难。为了应对这些挑战，研究人员正在开发和探索创新方法来对抗与生物膜相关的感染。本篇迷你综述重点介绍了以下关键领域的最新进展：表面抗粘附技术、电能、光/声激活材料、内源性模拟剂和创新药物输送系统。这些策略旨在预防生物膜形成、破坏现有的生物膜并增强抗菌治疗的效果。目前，这些方法在医疗器械和与伤口相关的生物膜感染等医学领域的应用中显示出巨大的潜力。通过总结这些进展，本篇迷你综述为寻求推进与生物膜相关感染的管理和治疗的研究人员提供了全面的资源。
