He Junchen, Huang Rong, Liu Yingzhu, Chen Ying, Zhong Min
The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
Department of Anesthesiology, Guangdong Provincial Hospital of Traditional Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Front Pharmacol. 2025 Apr 2;16:1562765. doi: 10.3389/fphar.2025.1562765. eCollection 2025.
Opioids have constituted an essential element of general anesthesia for a considerable length of time. However, with the increase in opioid misuse and associated postoperative adverse effects, studies related to opioid-free anesthesia (OFA) have emerged, which pose a challenge in identifying key research directions. Accordingly, the objective of this study was to provide a review of the relevant literature in the field of OFA over the past 2 decades, with the goal of identifying the prevailing trends and research Frontiers.
A systematic review of the publications on OFA was conducted using the Web of Science Core Collection database, with the objective of identifying relevant publications between the years 2005 and 2024. The bibliometric analysis was conducted using CiteSpace (version 6.1. R6), VOSviewer (version 1.6.19), and R (version4.4.2).
In conclusion, 477 publications were included in this study. The number of annual publications in this field has exhibited a steady increase over the past 2 decades. The United States and its institutions were found to be the most central. Forget, Patrice, and BELOEIL H were identified as the most prolific and highly cited authors, respectively. The journal with the highest number of publications was . The most frequently cited journal was , followed by . In addition, keyword burst, keywords co-occurrence, and analysis of cited references indicate that recent studies have focused on: opioid consumption, pain, and postoperative nausea and vomiting (PONV). Meanwhile, analysis of keyword clusters and keywords timeline view showed that the main research frontiers are sevoflurane anesthesia, plane block, multimodal anesthesia, opioid-sparing anesthesia.
Our results show that the current trends and directions of research focus on opioid consumption, pain, and PONV. Frontiers for future research are expected to include research areas related to sevoflurane anesthesia, plane block, multimodal anesthesia, opioid-sparing anesthesia.
在相当长的一段时间里，阿片类药物一直是全身麻醉的重要组成部分。然而，随着阿片类药物滥用情况的增加以及相关术后不良反应的出现，有关无阿片类药物麻醉（OFA）的研究应运而生，这给确定关键研究方向带来了挑战。因此，本研究的目的是对过去20年里OFA领域的相关文献进行综述，以确定主要趋势和研究前沿。
使用科学网核心合集数据库对关于OFA的出版物进行系统综述，目的是识别2005年至2024年期间的相关出版物。使用CiteSpace（版本6.1.R6）、VOSviewer（版本1.6.19）和R（版本4.4.2）进行文献计量分析。
本研究共纳入477篇出版物。在过去20年里，该领域的年出版物数量呈稳步增长。美国及其机构被发现处于最核心地位。Forget、Patrice和BELOEIL H分别被确定为发文量最多和被引频次最高的作者。发表文章数量最多的期刊是 。被引频次最高的期刊是 ，其次是 。此外，关键词突现、关键词共现以及被引参考文献分析表明，近期研究集中在：阿片类药物消耗量、疼痛以及术后恶心呕吐（PONV）。同时，关键词聚类分析和关键词时间线视图显示，主要研究前沿是七氟烷麻醉、平面阻滞、多模式麻醉、阿片类药物节省麻醉。
我们的结果表明，当前的研究趋势和方向集中在阿片类药物消耗量、疼痛和PONV。未来研究前沿预计将包括与七氟烷麻醉、平面阻滞、多模式麻醉、阿片类药物节省麻醉相关的研究领域。
