Xu Jun, Chen Ning, Li Zhou, Liu Yulan
Department of Gastroenterology, Peking University People's Hospital, Beijing 100044, China.
Clinical Center of Immune-Mediated Digestive Diseases, Peking University People's Hospital, Beijing 100044, China.
Fundam Res. 2024 Sep 24;5(2):890-901. doi: 10.1016/j.fmre.2024.09.007. eCollection 2025 Mar.
Symbiotic microbiota plays a crucial role in the education, development, and maintenance of the host immune system, significantly contributing to overall health. Through the gut-liver axis, the gut microbiota and liver have a bidirectional relationship that is becoming increasingly evident as more research highlights the translocation of the gut microbiota and its metabolites. The focus of this narrative review is to examine and discuss the importance of the gut-liver axis and the enterohepatic barrier in maintaining overall health. Additionally, we emphasize the crucial role of the gut microbiome in liver diseases and explore potential therapeutic strategies for liver diseases by manipulating the microbiota.
共生微生物群在宿主免疫系统的塑造、发育和维持中起着至关重要的作用,对整体健康有显著贡献。通过肠-肝轴,肠道微生物群与肝脏存在双向关系,随着越来越多的研究强调肠道微生物群及其代谢产物的易位,这种关系变得越来越明显。本叙述性综述的重点是研究和讨论肠-肝轴和肠肝屏障在维持整体健康中的重要性。此外,我们强调肠道微生物群在肝脏疾病中的关键作用,并探索通过调控微生物群来治疗肝脏疾病的潜在策略。