[Use of a culture of human peripheral blood lymphocytes for determining the mutagenic activity of urine].

The present study shows that the culture of human peripheral lymphocytes may be used as target cells for detecting the whole urine mutagenic activity. It is established that urine from healthy control cigarette smokers and from non-smoking greenhouse workers contacting with a complex of different pesticides significantly increased frequency of chromosome aberrations in the approbated test-system. The data obtained give evidence for the presence of genetically active substances in organisms of the examined individuals.