Sugimoto Takahiro, Hashida Ryuki, Iwanaga Sohei, Baba Eriko, Omoto Masayuki, Nakano Dan, Yoshio Sachiyo, Kawaguchi Takumi, Matsuse Hiroo
Division of Rehabilitation, Kurume University Hospital, Kurume, JPN.
Division of Gastroenterology, Kurume University Hospital, Kurume, JPN.
Cureus. 2025 Mar 17;17(3):e80694. doi: 10.7759/cureus.80694. eCollection 2025 Mar.
A hybrid training system (HTS) combining antagonist muscle electrical stimulation and voluntary muscle contraction has been developed using electrically stimulated eccentric antagonist muscle contractions. The exercise method that combines a conventional cycle ergometer with HTS (HERG) adds additional exercise intensity to the conventional cycle ergometer through electrical stimulation. Exercise-induced brain-derived neurotrophic factor (BDNF) production appears to have neuroprotective effects and contributes to improved metabolic regulation. Changes in BDNF after exercise are related to exercise intensity. Therefore, combining a cycle ergometer with electrical stimulation may be an effective approach.
The purpose of this study was to evaluate the effect of the HERG on BDNF secretion.
Fourteen healthy adults participated in the study. The participants performed two types of exercise at the anaerobic threshold: HERG and a cycling ergometer alone (CERG). A comparative study using a 2×2 crossover method was conducted to examine the differences in BDNF and lactate levels after HERG and CERG. A linear mixed model was used to compare changes in BDNF between HERG and CERG.
Both HERG and CERG significantly increased BDNF and lactate levels after exercise. In overweight individuals with a BMI of 25 or higher, the change in BDNF levels after HERG was significantly greater than after CERG [ΔBDNF: 5500.96±7965.83 ng/ml, 1921.29±5308.22 ng/ml, respectively; p=0.0339]. There was no significant difference in the change in lactate levels after exercise between HERG and CERG (p=0.8632).
In overweight individuals, HERG increased post-exercise serum BDNF levels more than ergometer exercise alone, despite the exercise intensity remaining the same at the anaerobic threshold. The exercise method that combines the HERG may be a useful form of exercise for overweight individuals.
一种结合拮抗肌电刺激和自主肌肉收缩的混合训练系统（HTS）已通过电刺激离心拮抗肌收缩得以开发。将传统自行车测力计与HTS相结合的运动方法（HERG）通过电刺激为传统自行车测力计增加了额外的运动强度。运动诱导的脑源性神经营养因子（BDNF）产生似乎具有神经保护作用，并有助于改善代谢调节。运动后BDNF的变化与运动强度有关。因此，将自行车测力计与电刺激相结合可能是一种有效的方法。
本研究的目的是评估HERG对BDNF分泌的影响。
14名健康成年人参与了本研究。参与者在无氧阈值下进行两种类型的运动：HERG和单独的自行车测力计运动（CERG）。采用2×2交叉法进行对比研究，以检查HERG和CERG后BDNF和乳酸水平的差异。使用线性混合模型比较HERG和CERG之间BDNF的变化。
HERG和CERG运动后均显著提高了BDNF和乳酸水平。在体重指数（BMI）为25或更高的超重个体中，HERG后BDNF水平的变化显著大于CERG后[ΔBDNF：分别为5500.96±7965.83 ng/ml、1921.29±5308.22 ng/ml；p = 0.0339]。HERG和CERG运动后乳酸水平变化无显著差异（p = 0.8632）。
在超重个体中，尽管在无氧阈值下运动强度保持相同，但HERG比单独的测力计运动更能提高运动后血清BDNF水平。结合HERG的运动方法可能是超重个体有用的运动形式。
