Giraud Nicolas, Tekatli Hilâl, Schneiders Famke L, van Sornsen de Koste John R, Marzo Marco, Palacios Miguel A, Senan Suresh
Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Radiation Oncology, Boelelaan 1117, Amsterdam, the Netherlands.
Cancer Center Amsterdam, Treatment and Quality of Life, Amsterdam, the Netherlands.
Phys Imaging Radiat Oncol. 2025 Apr 2;34:100761. doi: 10.1016/j.phro.2025.100761. eCollection 2025 Apr.
Higher toxicity rates are associated with stereotactic ablative radiotherapy (SABR) to central lung tumors. Breath-hold (BH) magnetic resonance-guided SABR (MR-SABR) can reduce doses to organs at risk (OAR). We quantified the planning target volumes (PTV) to OAR distance in 45 lesions treated using MR-SABR and generated a corresponding four-dimensional computed tomography (4D-CT) based PTV (motion-encompassing internal target volume plus 5 mm). For lesions located ≦3 cm from airways, BH MR-SABR increased the median PTV distance to OAR by 3.7 mm. For lesions ≦3 cm from pericardium, median PTV-OAR separation increased by 2.0 mm with BH. These findings highlight the advantage of BH SABR for central lung tumors.
较高的毒性发生率与立体定向消融放疗（SABR）治疗中央型肺肿瘤有关。屏气（BH）磁共振引导下的SABR（MR-SABR）可减少对危及器官（OAR）的剂量。我们对45个采用MR-SABR治疗的病灶的计划靶区（PTV）到OAR的距离进行了量化，并生成了相应的基于四维计算机断层扫描（4D-CT）的PTV（包含运动的内部靶区体积加5毫米）。对于距离气道≤3厘米的病灶，BH MR-SABR使PTV到OAR的中位距离增加了3.7毫米。对于距离心包≤3厘米的病灶，BH使PTV与OAR的中位间距增加了2.0毫米。这些发现突出了BH SABR治疗中央型肺肿瘤的优势。
