Paget-Blanc Alexandra, Thurston Rebecca C, Smagula Stephen F, Chang Yuefang, Maki Pauline M
Department of Psychiatry University of Illinois at Chicago Chicago Illinois USA.
Department of Psychiatry, School of Medicine University of Pittsburgh Pittsburgh Pennsylvania USA.
Alzheimers Dement (Amst). 2025 Apr 15;17(2):e70105. doi: 10.1002/dad2.70105. eCollection 2025 Apr-Jun.
Disrupted rest-activity rhythms (RARs) have been linked to poorer cognitive function and Alzheimer's disease (AD) biomarkers. Here we extend this work to midlife women, who commonly experience menopause-related sleep and cognitive problems.
One hundred ninety-four postmenopausal participants underwent a neuropsychological evaluation, 72 h of wrist actigraphy generating RAR variables, and a blood draw to measure AD biomarkers: phosphorylated tau (p-tau181, p-tau231) and amyloid beta (Aβ40, Aβ42).
Lower interdaily stability (IS) and relative amplitude (RA) and higher interdaily variability (IV) and least active 5 h (L5) were associated with worse processing speed, independent of sleep. Adjustment for sleep significantly attenuated the associations of RA with memory. Lower RA was associated with higher p-tau231 level, independent of sleep. Further adjustment for menopause-related factors modestly accounted for the associations between RAR, cognitive measures, and AD biomarkers.
Weaker RAR, particularly RA, was associated with worse cognitive functions, and higher AD biomarkers levels, possibly linking RAR with AD pathology in women.
Lower rhythm stability and robustness and higher fragmentation were associated with worse processing speed.Lower robustness was associated with higher levels of phosphorylated tau-231.Menopause factors did not attenuate the association between rest-activity rhythms and cognitive function.
休息-活动节律（RARs）紊乱与较差的认知功能和阿尔茨海默病（AD）生物标志物有关。在此，我们将这项研究扩展到中年女性，她们通常会经历与更年期相关的睡眠和认知问题。
194名绝经后参与者接受了神经心理学评估、72小时的腕部活动记录仪监测以生成RAR变量，并进行了血液抽取以测量AD生物标志物：磷酸化tau蛋白（p-tau181、p-tau231）和淀粉样β蛋白（Aβ40、Aβ42）。
较低的日间稳定性（IS）和相对振幅（RA）以及较高的日间变异性（IV）和最不活跃的5小时（L5）与较差的处理速度相关，且与睡眠无关。对睡眠进行调整后，显著减弱了RA与记忆之间的关联。较低的RA与较高的p-tau231水平相关，且与睡眠无关。进一步对与更年期相关的因素进行调整后，适度解释了RAR、认知指标和AD生物标志物之间的关联。
较弱的RAR，尤其是RA，与较差的认知功能和较高的AD生物标志物水平相关，这可能将RAR与女性的AD病理联系起来。
较低的节律稳定性和稳健性以及较高的碎片化程度与较差的处理速度相关。较低的稳健性与较高水平的磷酸化tau-231相关。更年期因素并未减弱休息-活动节律与认知功能之间的关联。
