Xu Rongmei, Kang Qiaoju, Yang Xuefei, Yi Ping, Zhang Rongying
School of Biotechnology and Food Engineering, Hefei University of Technology, Hefei 230002, China.
Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Int J Mol Sci. 2025 Mar 26;26(7):3030. doi: 10.3390/ijms26073030.
Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), and prion disease, represent a group of age-related disorders that pose a growing and formidable challenge to global health. Despite decades of extensive research that has uncovered key genetic factors and biochemical pathways, the precise molecular mechanisms underlying these diseases and effective therapeutic strategies remain elusive. () has emerged as a powerful model organism for studying NDDs due to its unique biological features such as genetic tractability, conserved molecular pathways, and ease of high-throughput screening. This model provides an exceptional platform for identifying molecular targets associated with NDDs and developing novel therapeutic interventions. This review highlights the critical role of in elucidating the complex molecular mechanisms of human NDDs, with a particular focus on recent advancements and its indispensable contributions to the discovery of molecular targets and therapeutic strategies for these NDDs.
神经退行性疾病（NDDs），包括阿尔茨海默病（AD）、帕金森病（PD）、肌萎缩侧索硬化症（ALS）、亨廷顿病（HD）和朊病毒病，是一组与年龄相关的疾病，对全球健康构成了日益严峻的挑战。尽管经过数十年的广泛研究，已经发现了关键的遗传因素和生化途径，但这些疾病背后的确切分子机制和有效的治疗策略仍然难以捉摸。（）由于其独特的生物学特性，如遗传易处理性、保守的分子途径和易于进行高通量筛选，已成为研究神经退行性疾病的强大模式生物。该模式为识别与神经退行性疾病相关的分子靶点和开发新的治疗干预措施提供了一个特殊的平台。本综述强调了（）在阐明人类神经退行性疾病复杂分子机制中的关键作用，特别关注了最近的进展及其对这些神经退行性疾病分子靶点和治疗策略发现的不可或缺的贡献。
