Rani Nisha, Alam Mohammad Mumtaz, Jamal Azfar, Bin Ghaffar Usama, Parvez Suhel
Department of Toxicology, School of Chemical & Life Sciences, Jamia Hamdard, New Delhi 110062, India.
Drug Design and Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
Ageing Res Rev. 2023 Nov;91:102036. doi: 10.1016/j.arr.2023.102036. Epub 2023 Aug 19.
Neurodegenerative diseases (NDs) are a heterogeneous group of aging-associated ailments characterized by interrupting cellular proteostasic machinery and the misfolding of distinct proteins to form toxic aggregates in neurons. Neurodegenerative diseases, which include Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), and others, are becoming an increasing threat to human health worldwide. The degeneration and death of certain specific groups of neurons are the hallmarks of these diseases. Over the past decades, Caenorhabditis eleganshas beenwidely used as a transgenic model to investigate biological processes related to health and disease. The nematode Caenorhabditis elegans (C. elegans) has developed as a powerful tool for studying disease mechanisms due to its ease of genetic handling and instant cultivation while providing a whole-animal system amendable to several molecular and biochemical techniques. In this review, we elucidate the potential of C. elegans as a versatile platform for systematic dissection of the molecular basis of human disease, focusing on neurodegenerative disorders, and may help better our understanding of the disease mechanisms and search for new therapeutics for these devastating diseases.
神经退行性疾病（NDs）是一组与衰老相关的异质性疾病，其特征是细胞蛋白质稳态机制中断，以及特定蛋白质错误折叠形成有毒聚集体并在神经元中积累。神经退行性疾病包括阿尔茨海默病（AD）、帕金森病（PD）、肌萎缩侧索硬化症（ALS）、亨廷顿舞蹈病（HD）等，正日益成为全球人类健康的一大威胁。特定神经元群体的退化和死亡是这些疾病的标志。在过去几十年里，秀丽隐杆线虫已被广泛用作转基因模型来研究与健康和疾病相关的生物学过程。线虫秀丽隐杆线虫（C. elegans）因其易于进行基因操作和快速培养，同时提供了一个适用于多种分子和生化技术的全动物系统，已发展成为研究疾病机制的有力工具。在这篇综述中，我们阐明了秀丽隐杆线虫作为一个多功能平台用于系统剖析人类疾病分子基础的潜力，重点关注神经退行性疾病，这可能有助于我们更好地理解疾病机制，并为这些毁灭性疾病寻找新的治疗方法。
