Li Ning, Wu Qian, Huang Yu, Shi Enxue, Li Junchen
State Key Laboratory of NBC Protection for Civilian, Beijing 102205, China.
Int J Mol Sci. 2025 Mar 27;26(7):3065. doi: 10.3390/ijms26073065.
The [1,2]-phospha-Brook rearrangement serves as a powerful synthetic strategy that enables efficient carbonyl umpolung through phosphoryl group migration, providing direct access to α-hydroxyphosphoryl compounds-a privileged class of synthons with broad applications in organophosphorus chemistry, medicinal chemistry, and materials science. This review provides a comprehensive overview of recent progress in synthetic methodologies, possible mechanisms, and asymmetric transformations, highlighting key breakthroughs and future directions in this rapidly evolving field.
[1,2]-磷-Brook重排是一种强大的合成策略，它能够通过磷酰基迁移实现高效的羰基极性翻转，直接得到α-羟基磷酰基化合物——这是一类在有机磷化学、药物化学和材料科学中具有广泛应用的重要合成子。本综述全面概述了合成方法、可能的机理以及不对称转化方面的最新进展，突出了这个快速发展领域的关键突破和未来方向。
