Aoki Yoshitaka, Kondo Satoru, Kobayashi Eiji, Moriyama-Kita Makiko, Dochi Hirotomo, Komura Shigetaka, Nakanishi Yosuke, Endo Kazuhira, Wakisaka Naohiro, Yoshizaki Tomokazu
Division of Otolaryngology and Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8640, Ishikawa, Japan.
Department of Otorhinolaryngology, NHO Kanazawa Medical Center, Kanazawa 920-8650, Ishikawa, Japan.
Int J Mol Sci. 2025 Mar 30;26(7):3223. doi: 10.3390/ijms26073223.
Human papillomavirus (HPV) is a known risk factor for oropharyngeal cancer (OPC), with distinct HPV-positive and HPV-negative subtypes. Reactive oxygen species have been implicated in the carcinogenesis of several malignancies. Superoxide dismutase 2 (SOD2), a mitochondrial enzyme, is highly influenced by oxidative stress. This study investigated whether SOD1 and SOD2 expression in OPC affects primary tumor progression, lymph node metastasis, stage, and overall survival (OS). Biopsy or surgically resected specimens from 72 patients with OPC were analyzed via immunohistochemical staining for SOD1 and SOD2. The proportion of stained cells within the tumor area was assessed. Associations between SOD1 and SOD2 expression, T classification, N classification, and stage were evaluated. Factors correlated with OS in OPC were also examined. No significant differences in SOD1 or SOD2 expression were observed concerning T or N classification, or stage. However, high SOD2 expression was identified as a significant poor prognostic factor for OS. Regardless of HPV status, SOD2 expression predicts poor prognosis in OPC. Evaluating SOD2 expression may help predict OPC prognosis.
人乳头瘤病毒（HPV）是口咽癌（OPC）的已知风险因素，存在不同的HPV阳性和阴性亚型。活性氧已被认为与几种恶性肿瘤的致癌作用有关。超氧化物歧化酶2（SOD2）是一种线粒体酶，受氧化应激的影响很大。本研究调查了OPC中SOD1和SOD2的表达是否会影响原发性肿瘤进展、淋巴结转移、分期和总生存期（OS）。通过对72例OPC患者的活检或手术切除标本进行SOD1和SOD2免疫组化染色分析。评估肿瘤区域内染色细胞的比例。评估SOD1和SOD2表达与T分类、N分类和分期之间的关联。还检查了与OPC中OS相关的因素。在T或N分类或分期方面，未观察到SOD1或SOD2表达有显著差异。然而，高SOD2表达被确定为OS的一个显著不良预后因素。无论HPV状态如何，SOD2表达均可预测OPC的不良预后。评估SOD2表达可能有助于预测OPC预后。
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