Zhang Enhao, Yan Xu, Shen Hangyu, Zhao Mingyue, Gao Xiang, Huang Yi
Ningbo Key Laboratory of Nervous System and Brain Function, Department of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo 315010, China.
Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province, Ningbo 315010, China.
Int J Mol Sci. 2025 Apr 2;26(7):3316. doi: 10.3390/ijms26073316.
Intracranial aneurysm (IA) is a common cerebrovascular disease in which sacral aneurysms occurring in the Wills ring region can lead to devastating subarachnoid hemorrhage. Despite advances in research, the underlying mechanisms of IA formation and rupture remain incompletely understood, hindering early diagnosis and effective treatment. This review comprehensively summarizes the current landscape of IA biomarkers, encompassing genetic markers, DNA, RNA, inflammatory molecules, oxidative stress proteins, and extracellular matrix (ECM) components. Accumulating evidence suggests that various biomarkers are associated with different stages of IA pathogenesis, including initiation, progression, and rupture. Aberrant ECM composition and remodeling have been observed in IA patients, and extracellular matrix-degrading enzymes are implicated in IA growth and rupture. Biomarker research in IA holds great potential for improving clinical outcomes. Future studies should focus on validating the existing biomarkers, identifying novel ones, and investigating their underlying mechanisms to facilitate the development of personalized preventive and therapeutic strategies for IA.
颅内动脉瘤（IA）是一种常见的脑血管疾病，其中发生在Willis环区域的囊性动脉瘤可导致毁灭性的蛛网膜下腔出血。尽管研究取得了进展，但IA形成和破裂的潜在机制仍未完全明确，这阻碍了早期诊断和有效治疗。本综述全面总结了IA生物标志物的当前情况，包括遗传标志物、DNA、RNA、炎症分子、氧化应激蛋白和细胞外基质（ECM）成分。越来越多的证据表明，各种生物标志物与IA发病机制的不同阶段相关，包括起始、进展和破裂。在IA患者中观察到细胞外基质组成异常和重塑，细胞外基质降解酶与IA的生长和破裂有关。IA的生物标志物研究在改善临床结果方面具有巨大潜力。未来的研究应专注于验证现有生物标志物、识别新的生物标志物，并研究其潜在机制，以促进IA个性化预防和治疗策略的发展。
