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儿童连续性肾脏替代治疗

Continuous Renal Replacement Therapy in Children.

作者信息

Haddad Maha, Butani Lavjay

机构信息

Division of Pediatric Nephrology, Department of Pediatrics, University of California, Davis, 2516 Stockton Blvd, Sacramento, CA, 95817, USA.

出版信息

Indian Pediatr. 2025 Apr;62(4):295-299. doi: 10.1007/s13312-025-00026-4.

DOI:10.1007/s13312-025-00026-4
PMID:40244308
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12006231/
Abstract

Continuous renal replacement (CRRT) therapies are a valuable addition to the dialytic armamentarium, and that, through gentler fluid removal and solute clearance, are better tolerated in critically ill children who are in need of dialysis. CRRT is technically demanding and resource intensive, and its use can be associated with many complications. There are many different modalities of CRRT, each of which employ varying combinations of convective and diffuse solute removal and ultrafiltration. CRRT is performed using specialized devices with their own unique dialysis filters and options for different circuit anticoagulation modalities. Because of the complexities inherent in the choice of CRRT and the monitoring involved, CRRT must be performed an intensive care unit setting, using a multidisciplinary team approach.

摘要

持续肾脏替代治疗(CRRT)是透析设备中的一项重要补充,通过更温和的液体清除和溶质清除,对于需要透析的危重症儿童耐受性更好。CRRT技术要求高且资源消耗大,其使用可能与许多并发症相关。CRRT有许多不同的模式,每种模式采用对流和扩散溶质清除及超滤的不同组合。CRRT使用具有独特透析滤器和不同回路抗凝模式选项的专用设备进行。由于CRRT选择和监测中固有的复杂性,CRRT必须在重症监护病房环境中,采用多学科团队方法进行。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9145/12006231/9ddfd3191a0b/13312_2025_26_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9145/12006231/9ddfd3191a0b/13312_2025_26_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9145/12006231/9ddfd3191a0b/13312_2025_26_Fig1_HTML.jpg

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1
Continuous Renal Replacement Therapy in Children.儿童连续性肾脏替代治疗
Indian Pediatr. 2025 Apr;62(4):295-299. doi: 10.1007/s13312-025-00026-4.
2
Continuous Renal Replacement Therapy: Who, When, Why, and How.连续性肾脏替代治疗:谁、何时、为何以及如何。
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3
Continuous renal replacement therapy is associated with acute cardiac stunning in critically ill patients.持续肾脏替代疗法与危重症患者的急性心脏顿抑有关。
Hemodial Int. 2019 Jul;23(3):325-332. doi: 10.1111/hdi.12760. Epub 2019 May 15.
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J Crit Care. 2024 Aug;82:154764. doi: 10.1016/j.jcrc.2024.154764. Epub 2024 Mar 8.

本文引用的文献

1
Factors influencing circuit lifetime in paediatric continuous kidney replacement therapies - results from the EurAKId registry.影响儿科连续性肾脏替代治疗中回路寿命的因素 - EurAKId 登记处的结果。
Pediatr Nephrol. 2024 Nov;39(11):3353-3362. doi: 10.1007/s00467-024-06459-6. Epub 2024 Jul 18.
2
Concurrent use of continuous kidney replacement therapy during extracorporeal membrane oxygenation: what pediatric nephrologists need to know-PCRRT-ICONIC practice points.体外膜肺氧合期间连续肾脏替代治疗的同时使用:儿科肾脏病医生需要知道的- PCRRT-ICONIC 实践要点。
Pediatr Nephrol. 2025 Jan;40(1):267-284. doi: 10.1007/s00467-024-06311-x. Epub 2024 Feb 22.
3
Continuous renal replacement therapy in neonates and children: what does the pediatrician need to know? An overview from the Critical Care Nephrology Section of the European Society of Paediatric and Neonatal Intensive Care (ESPNIC).
新生儿及儿童的连续性肾脏替代治疗:儿科医生需要了解什么?欧洲儿科和新生儿重症监护学会(ESPNIC)重症监护肾脏病学组的综述
Eur J Pediatr. 2024 Feb;183(2):529-541. doi: 10.1007/s00431-023-05318-0. Epub 2023 Nov 17.
4
Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial.起始连续性肾脏替代治疗与间歇性血液透析在重症急性肾损伤患者中的比较:STARRT-AKI 试验的二次分析。
Intensive Care Med. 2023 Nov;49(11):1305-1316. doi: 10.1007/s00134-023-07211-8. Epub 2023 Oct 10.
5
Efficacy of Continuous Renal Replacement Therapy and Intermittent Hemodialysis in Patients with Renal Failure in Intensive Care Unit: A Systemic Review and Meta-analysis.持续肾脏替代治疗与间歇性血液透析在重症监护病房肾衰竭患者中的疗效:一项系统评价与Meta分析
Evid Based Complement Alternat Med. 2023 Apr 17;2023:8688974. doi: 10.1155/2023/8688974. eCollection 2023.
6
Literature Review of the Efficacy of High-Volume Hemofiltration in Critically Ill Pediatric Patients.高容量血液滤过治疗危重症儿科患者疗效的文献复习。
Blood Purif. 2022;51(8):649-659. doi: 10.1159/000520519. Epub 2022 Apr 25.
7
Strategies for Continuous Renal Replacement Therapy De-escalation.持续肾脏替代治疗降级策略。
Kidney360. 2021 Apr 15;2(7):1166-1169. doi: 10.34067/KID.0000912021. eCollection 2021 Jul 29.
8
Basics of continuous renal replacement therapy in pediatrics.儿科连续性肾脏替代治疗基础
Kidney Res Clin Pract. 2019 Dec 31;38(4):455-461. doi: 10.23876/j.krcp.19.060.
9
Timing of continuous renal replacement therapy and mortality in critically ill children*.危重症儿童连续性肾脏替代治疗时机与死亡率的关系*。
Crit Care Med. 2014 Apr;42(4):943-53. doi: 10.1097/CCM.0000000000000039.
10
The prospective pediatric continuous renal replacement therapy (ppCRRT) registry: a critical appraisal.前瞻性儿科连续性肾脏替代治疗(ppCRRT)登记处:一项批判性评估。
Pediatr Nephrol. 2014 Nov;29(11):2069-76. doi: 10.1007/s00467-013-2594-5. Epub 2013 Aug 28.