Renal fibrosis progression following partial unilateral ureteral obstruction: mechanisms and therapeutic insights.

Ureteral obstruction, a common clinical condition, is associated with various renal disorders affecting all age groups and can lead to permanent renal damage. In Partial unilateral ureteral obstruction (PUUO), increased ureteral pressure, and decreased glomerular filtration rate (GFR) in the affected kidney cause cellular and molecular abnormalities, which ultimately lead to renal fibrosis if untreated. While removing the obstruction (RUUO) is essential to prevent long-term damage, additional therapeutic approaches may be necessary to fully restore kidney function. The PUUO model is used to induce renal fibrosis, primarily characterized by tubular injury resulting from obstructed urine flow. PUUO in rodents can simulate human chronic obstructive nephropathy at an accelerated rate. Although alleviating the obstruction can reduce immediate symptoms, it is often insufficient to reverse established fibrosis, emphasizing the need for adjunctive therapies. The renal response to RUUO depends on factors like the obstruction's duration and severity, as well as the contralateral kidney's functional state.