Kumari Nishchhal, Addepalli Veeranjaneyulu, More Aniket, Patil Ashwani, Suryawanshi Meghraj
Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Pune, Maharashtra, 411018, India.
Department of Pharmaceutics, Sandip Institute of Pharmaceutical Sciences (SIPS), Affiliated To Savitribai Phule Pune University (SPPU, Pune), Nashik, Maharashtra, 422213, India.
Inflammopharmacology. 2025 Apr 17. doi: 10.1007/s10787-025-01726-w.
Increasingly recognized as a neurodegenerative disease with motor manifestations and progressive cognitive decline, PD has more frequently been linked to the gut microbiome. The gut-brain axis, a bidirectional communication system between the gut and brain, plays a crucial role in PD pathogenesis. Exploration of the intricacies in the interplay between PD and the gut microbiome, together with the important mechanisms involved, will form the basis of this review. Gut microbiome activities as contributors to PD actions include altered intestinal permeability, neuroinflammation, alpha-syn aggregation, oxidative stress, and neurotransmitter production. Gut-brain axis communication that is highly facilitated through immune, metabolic, and neural pathways enables communication between the gut and the brain. Recent evidence suggests that the disease may begin in the gut, with GI symptoms typically preceding loss of motor control. Research has shown a significant connection between Parkinson's disease and the gut microbiome, affecting disease onset, progression, and symptoms. Therapeutic strategies targeting the gut microbiome, such as probiotics, prebiotics, and FMT, may improve PD outcomes. Personalized medicine and neuroprotective therapies are promising for managing PD. Researchers are exploring the connection between the gut microbiome and PD to create new treatments for bettering the lives of those with the disease. By understanding the intricate relationship between the gut microbiome and PD, researchers can develop novel therapeutic approaches to improve the quality of life for individuals with this debilitating disease.
帕金森病（PD）越来越被认为是一种具有运动表现和进行性认知衰退的神经退行性疾病，它与肠道微生物群的联系也越来越频繁。肠-脑轴是肠道与大脑之间的双向通信系统，在PD发病机制中起着关键作用。探索PD与肠道微生物群之间相互作用的复杂性以及其中涉及的重要机制，将构成本综述的基础。肠道微生物群活动作为PD发病的促成因素，包括肠道通透性改变、神经炎症、α-突触核蛋白聚集、氧化应激和神经递质产生。通过免疫、代谢和神经途径高度促进的肠-脑轴通信实现了肠道与大脑之间的交流。最近的证据表明，该疾病可能始于肠道，胃肠道症状通常先于运动控制丧失出现。研究表明帕金森病与肠道微生物群之间存在显著联系，影响疾病的发病、进展和症状。针对肠道微生物群的治疗策略，如益生菌、益生元、粪菌移植，可能改善PD的治疗效果。个性化医疗和神经保护疗法在治疗PD方面前景广阔。研究人员正在探索肠道微生物群与PD之间的联系，以创造新的治疗方法来改善患者的生活。通过了解肠道微生物群与PD之间的复杂关系，研究人员可以开发新的治疗方法，以提高这种致残性疾病患者的生活质量。
