Chen Yu-Xin, Zhao Guang-Nian, Gao Qing-Lei
Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430030, China.
Key Laboratory of Cancer Invasion and Metastasis (Ministry of Education), Hubei Key Laboratory of Tumor Invasion and Metastasis, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430030, China.
Curr Med Sci. 2025 Apr 17. doi: 10.1007/s11596-025-00041-3.
Ovarian cancer (OC), a highly lethal gynaecological malignancy, is often diagnosed at advanced stages, resulting in a poor prognosis. Sialylation, an important form of glycosylation, significantly contributes to the progression of various solid tumours, including OC. Aberrant sialylation promotes tumour progression and metastasis by altering the structure and function of glycoproteins. Although its role in several solid tumours is well documented, the role of abnormal sialylation in OC and its potential as a therapeutic target remain poorly understood. This review highlights sialylation as a key regulator of the progression, metastasis, and drug resistance of OC. A deeper understanding of altered sialylation can contribute to the identification of novel therapeutic strategies for OC.
卵巢癌（OC）是一种极具致死性的妇科恶性肿瘤，通常在晚期才被诊断出来，预后较差。唾液酸化是糖基化的一种重要形式，对包括OC在内的各种实体瘤的进展有显著影响。异常唾液酸化通过改变糖蛋白的结构和功能促进肿瘤进展和转移。尽管其在几种实体瘤中的作用已有充分记载，但异常唾液酸化在OC中的作用及其作为治疗靶点的潜力仍知之甚少。本综述强调唾液酸化是OC进展、转移和耐药性的关键调节因子。对唾液酸化改变的更深入理解有助于确定OC的新型治疗策略。
