Zare Hosseinabadi Vahid, Abdi Fatemeh, Parvin Sadaf, Hemmati Sara, Chaibakhsh Samira
Department of Ophthalmology, Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran.
School of Medicine, Iran University of Medical Sciences, Tehran.
Indian J Ophthalmol. 2025 Jun 1;73(6):816-821. doi: 10.4103/IJO.IJO_962_24. Epub 2025 Apr 17.
This meta-analysis evaluates optical coherence tomography angiography (OCTA) results in macular telangiectasia (MacTel) type 2, a rare retinal condition marked by vascular abnormalities. We analyzed 26 studies for OCTA findings in MacTel type 2. We examined parameters like best corrected visual acuity (BCVA), foveal avascular zone (FAZ), and superficial and deep capillary plexus densities. The pooled mean BCVA was 0.37 log of minimum angle of resolution (20/50). FAZ enlargement was observed, with a pooled mean FAZ size of 0.39 mm 2 . Foveal deep vascular density (FDVD) and parafoveal superficial vascular density (PSVD) were significantly reduced ( P = 0.021 and P < 0.001, respectively). Parafoveal deep vascular density (PDVD) and foveal superficial vascular density (FSVD) did not decrease significantly ( P = 0.067 and 0.114, respectively). MacTel type 2 has unique OCTA characteristics, including reduced FDVD, PSVD, and enlarged FAZ. However, FSVD and PDVD did not statistically decrease in patients. Future studies using more parameters are required to expand our understanding.
这项荟萃分析评估了光学相干断层扫描血管造影（OCTA）在2型黄斑毛细血管扩张症（MacTel）中的结果，这是一种以血管异常为特征的罕见视网膜疾病。我们分析了26项关于2型MacTel的OCTA研究结果。我们检查了最佳矫正视力（BCVA）、黄斑无血管区（FAZ）以及浅表和深层毛细血管丛密度等参数。汇总的平均BCVA为最小分辨角对数（20/50）的0.37。观察到FAZ增大，汇总的平均FAZ大小为0.39平方毫米。黄斑深层血管密度（FDVD）和黄斑旁浅表血管密度（PSVD）显著降低（分别为P = 0.021和P < 0.001）。黄斑旁深层血管密度（PDVD）和黄斑浅表血管密度（FSVD）没有显著降低（分别为P = 0.067和0.114）。2型MacTel具有独特的OCTA特征，包括FDVD、PSVD降低以及FAZ增大。然而，患者的FSVD和PDVD在统计学上并没有降低。需要未来使用更多参数的研究来扩大我们的认识。
