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死于急性白血病患者的侵袭性曲霉病

[Invasive aspergillosis in patients who died from acute leukemia].

作者信息

Gerdzhikova P, Krŭstev D, Georgieva B

出版信息

Vutr Boles. 1985;24(1):127-33.

PMID:4024602
Abstract

The necropsy material with acute leukosis (166 deceased) was studied in order to establish the incidence of invasive aspergillosis. It was established in 16 of the deceased (9,64%): aspergillosis pneumonia--in 5 cases, aspergillosis sepsis--in II, with invasion of lungs, brain, spleen, liver, myocardium and other organs. Clinically aspergillosis was not distinguished. Continuous septic temperature, not influenced by antibiotic therapy should draw the attention to the presence of aspergillosis. The factors, preconditioning aspergillosis infection are stressed upon: immune-suppressive treatment in acute leukosis, granulocytopenia, continuous preceding antibiotic therapy, etc. The difficulties in the clinical differentiation of the infection are emphasized. With a view to the high incidence and lethality of aspergillosis in acute leukosis, the introduction of modern diagnostic methods and treatment are underlined to be necessary.

摘要

为确定侵袭性曲霉病的发病率,对患有急性白血病的尸检材料(166例死者)进行了研究。在16例死者(9.64%)中确诊:曲霉性肺炎5例,曲霉性败血症11例,肺部、脑、脾、肝、心肌及其他器官均有侵袭。临床上未区分出曲霉病。持续的败血症热,不受抗生素治疗影响,应引起对曲霉病存在的关注。强调了曲霉病感染的预处理因素:急性白血病中的免疫抑制治疗、粒细胞减少、持续的先前抗生素治疗等。强调了感染临床鉴别诊断中的困难。鉴于急性白血病中曲霉病的高发病率和致死率,强调有必要引入现代诊断方法和治疗。

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