Gao X, Xiang W
The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou Third People's Hospital, Hangzhou, Zhejiang, People's Republic of China.
Department of Dermatology, Hangzhou Third People's Hospital, Hangzhou, Zhejiang, People's Republic of China.
Actas Dermosifiliogr. 2025 Sep;116(8):863-875. doi: 10.1016/j.ad.2024.12.026. Epub 2025 Apr 15.
Topical interventions for rosacea are often used to relieve local symptoms. However, currently, there are few articles to systematically analyze the efficacy profile of topical drugs for rosacea. This study aimed to investigate the efficacy profile of widely used topical drugs. To acquire appropriate information from related literature, we looked into 4 databases. Efficacy was appraised with the Investigator Global Assessment, Clinician's Erythema Assessment, Patient's Self-Assessment and Subject Self-Assessment of Rosacea Facial Redness scales. Treatment-emergent adverse events and dermal tolerability were also recorded. According to 21 randomized controlled trials included, a total of 6 topical drugs including minocycline, ivermectin, azelaic acid, metronidazole, brimonidine and oxymetazoline were reported. These drugs are well-tolerated and safe. Ivermectin is more effective than azelaic acid and metronidazole. Azelaic acid has a better efficacy profile than metronidazole according to included studies. Minocycline turned out to be effective improving the symptoms of rosacea. Brimonidine and oxymetazoline both have significant effects on reducing facial redness.
酒渣鼻的局部干预措施常用于缓解局部症状。然而，目前很少有文章系统分析治疗酒渣鼻的局部药物的疗效。本研究旨在调查广泛使用的局部药物的疗效。为了从相关文献中获取适当的信息，我们检索了4个数据库。疗效通过研究者整体评估、临床医生红斑评估、患者自我评估和酒渣鼻面部发红量表的受试者自我评估来评价。还记录了治疗中出现的不良事件和皮肤耐受性。根据纳入的21项随机对照试验，共报告了6种局部药物，包括米诺环素、伊维菌素、壬二酸、甲硝唑、溴莫尼定和羟甲唑啉。这些药物耐受性良好且安全。伊维菌素比壬二酸和甲硝唑更有效。根据纳入的研究，壬二酸的疗效优于甲硝唑。米诺环素被证明对改善酒渣鼻症状有效。溴莫尼定和羟甲唑啉对减轻面部发红均有显著效果。
