Stoĭnov S, Nikolov N, Savov G, Ivanov E, Donchev N
Vutr Boles. 1985;24(3):29-33.
Thirty two patients were studied with chronic enterocolitis and 9 patients without any small intestinal diseases, with normal histomorphological picture of small intestinal mucosa--control group. The method of simultaneous performance of perfusion and biopsy of small intestine was used. Glucose resorption rate in small intestine was studied and histomorphological, electron--microscopic and enzymologic (disaccharidases) studies were carried out on jejunal mucosa. Data about chronic enterocolitis without atrophy were established in 17 patients, in 10--initial partial atrophy, in 5--advanced partial and subtotal atrophy of jejunal mucosa. Reduced glucose resorption rate was established in small intestine in the patients with chronic enterocolitis as compared with that of the control group. Glucose resorption rate correlates with the severity of the histomorphological changes in small intestinal mucosa. Disturbed resorption rate was established via jejuno--perfusion in patients with clinically not manifested syndrome of malresorption and absence of histomorphological changes in small intestinal mucosa, but with established ultrastructural changes in enterocytes.
对32例慢性小肠结肠炎患者以及9例无任何小肠疾病、小肠黏膜组织形态学正常的患者（对照组）进行了研究。采用了小肠灌注和活检同步进行的方法。研究了小肠的葡萄糖吸收速率，并对空肠黏膜进行了组织形态学、电子显微镜和酶学（双糖酶）研究。在17例患者中确定了无萎缩的慢性小肠结肠炎数据，10例为初始部分萎缩，5例为空肠黏膜的晚期部分和次全萎缩。与对照组相比，慢性小肠结肠炎患者小肠的葡萄糖吸收速率降低。葡萄糖吸收速率与小肠黏膜组织形态学变化的严重程度相关。在临床无吸收不良综合征表现且小肠黏膜无组织形态学变化但肠细胞有超微结构变化的患者中，通过空肠灌注确定了吸收速率紊乱。
