May E L, Jacobson A E
J Pharm Sci. 1977 Feb;66(2):285-6. doi: 10.1002/jps.2600660242.
3,6-Diformyl- and 3,6-dipropanoylmorphine and 6-formyl- and 6-propanoylmorphine were prepared to obtain longer acting, heroin-like compounds. The 6-acylated compounds were more potent than heroin subcutaneously and were orally effective, and their duration of action was at least two to three times greater than that of heroin in monkey species.
制备了3,6 -二甲酰基吗啡、3,6 -二丙酰基吗啡、6 -甲酰基吗啡和6 -丙酰基吗啡，以获得作用时间更长的类海洛因化合物。6 -酰化的化合物皮下注射时比海洛因更有效，且口服也有效，在猴类动物中其作用持续时间比海洛因至少长两到三倍。
