Liang Ya-Nan, Chen Luo, Huang Qing-Yu, Song Yu-Ting, Fan Yu-Juan, Chen Tong-Qing, Ni Jia-Hui, Wang Dong, Shen Xiao-Yan, Wang Yi-Ming, You Yan
Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, 201203, China.
Acta Pharmacol Sin. 2025 Apr 17. doi: 10.1038/s41401-025-01554-2.
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by a progressive breakdown of immune tolerance to self-antigens, resulting in multiple tissue damage and clinical symptoms. Innate and adaptive immune cells including dendritic cells, macrophages, myeloid-derived suppressor cells (MDSCs), T cells and B cells are the key drivers in perpetuating and amplifying of this systemic disease. In this review we offer a comprehensive overview of recent advances in understanding the immune-pathogenesis of SLE with particular emphasis on regulatory immune cells exhibiting immunosuppressive properties, as well as newly identified factors influencing immune cell function and lineage differentiation. Furthermore, we discuss traditional Chinese medicine and natural extracts that have shown therapeutic effects on SLE by modulating immune cell differentiation and function, which may provide insights into their clinical applications.
系统性红斑狼疮（SLE）是一种异质性自身免疫性疾病，其特征是对自身抗原的免疫耐受性进行性破坏，导致多组织损伤和临床症状。包括树突状细胞、巨噬细胞、髓源性抑制细胞（MDSC）、T细胞和B细胞在内的固有免疫细胞和适应性免疫细胞是这种全身性疾病持续存在和加剧的关键驱动因素。在这篇综述中，我们全面概述了在理解SLE免疫发病机制方面的最新进展，特别强调具有免疫抑制特性的调节性免疫细胞，以及新发现的影响免疫细胞功能和谱系分化的因素。此外，我们还讨论了通过调节免疫细胞分化和功能对SLE显示出治疗作用的中药和天然提取物，这可能为它们的临床应用提供见解。
