二膦酸盐处理大鼠的钙吸收：甲状旁腺功能、膳食钙和磷的影响
Calcium absorption in diphosphonate-treated rats: effect of parathyroid function, dietary calcium and phosphorus.
作者信息
Bonjour J P, Fleisch H, Trechsel U
出版信息
J Physiol. 1977 Jan;264(1):125-39. doi: 10.1113/jphysiol.1977.sp011660.
Abstract
- The role of parathyroid hormone (PTH) and 1, 25-dihydroxy-cholecalciferol (1,25-(OH)2D3) in modulation of intestinal Ca absorption was studied in rats, using disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP), which is known to reduce 1,25-(OH)2D3 formation. 2. EHDP decreased intestinal Ca absorption. This effect could be abolished by small amounts of 1,25-(OH)2D3, whereas even large doses of PTH were ineffective. EHDP also decreased Ca absorption in thyroparathyroidectomized (TPTX) rats. Therefore the effect of EHDP on 1,25-(OH)2D3 production is unlikely to be mediated through PTH. 3. The correction by PTH of the decreased Ca absorption in TPTX rats was inhibited by EHDP. Since EHDP inhibits formation of 1,25-(OH)2D3 the effect of PTH on Ca absorption is likely to be mediated through this vitamin D3 metabolite. 4. In normal rats both a low Ca and a low P diet stimulated Ca absorption. In EHDP-treated intact rats low Ca still stimulated Ca absorption, whereas the effect of low P abolished. This indicates that low Ca and low P diets affect Ca absorption through different mechanisms. 5. Intestinal adaptation to a low Ca diet was still observed in EHDP-treated TPTX rats. Thus, in the rat, intestinal adaptation to low Ca diet can occur without PTH.
摘要
- 使用已知可减少1,25 - 二羟基胆钙化醇（1,25-(OH)₂D₃）形成的1 - 羟基 - 1,1 - 二磷酸乙烷二钠（EHDP），在大鼠中研究了甲状旁腺激素（PTH）和1,25 - 二羟基胆钙化醇（1,25-(OH)₂D₃）对肠道钙吸收的调节作用。2. EHDP降低了肠道钙吸收。少量的1,25-(OH)₂D₃可消除这种作用，而即使大剂量的PTH也无效。EHDP还降低了甲状腺甲状旁腺切除（TPTX）大鼠的钙吸收。因此，EHDP对1,25-(OH)₂D₃产生的影响不太可能通过PTH介导。3. EHDP抑制了PTH对TPTX大鼠降低的钙吸收的纠正作用。由于EHDP抑制1,25-(OH)₂D₃的形成，PTH对钙吸收的作用可能通过这种维生素D₃代谢物介导。4. 在正常大鼠中，低钙和低磷饮食均刺激钙吸收。在EHDP处理的完整大鼠中，低钙仍刺激钙吸收，而低磷的作用则被消除。这表明低钙和低磷饮食通过不同机制影响钙吸收。5. 在EHDP处理的TPTX大鼠中仍观察到肠道对低钙饮食的适应性。因此，在大鼠中，肠道对低钙饮食的适应性可在没有PTH的情况下发生。
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