多囊卵巢综合征患者腰高比与胰岛素抵抗的相关性：一项荟萃分析。
Association between waist-to-height ratio and insulin resistance in patients with polycystic ovary syndrome: a meta-analysis.
作者信息
Lan Yuxiang, Zhong Chaohao, Li Dujin, Chen Haobin, Dai Xu
机构信息
Foshan Clinical Medical School, Guangzhou University of Chinese Medicine, Foshan, Guangdong, China.
The First Clinical College, Zunyi Medical University, Zunyi, Guizhou, China.
出版信息
Front Endocrinol (Lausanne). 2025 Apr 3;16:1567787. doi: 10.3389/fendo.2025.1567787. eCollection 2025.
BACKGROUND
Insulin resistance (IR) is regarded as a significant role in the pathophysiology of Polycystic Ovary Syndrome (PCOS), hence early identification of IR in PCOS patients is crucial for their treatment. Recent researches indicate that Waist-to-Height Ratio (WHtR) differs in patients with PCOS accompanied by IR compared to those with PCOS alone; however, a consensus has yet to be reached. This research presents a meta-analysis of current data to propose a straightforward new index for diagnosing PCOS with insulin resistance.
OBJECTIVE
This study aims to assess the correlation between WHtR and insulin resistance in individuals with polycystic ovarian syndrome by meta-analysis and the synthesis of research information. This study will offer prognostic insights into the onset of insulin resistance in individuals with polycystic ovaries.
METHODS
This systematic review has finalized registration (CRD42025638798) on the PROSPERO platform. We conducted a search of prominent databases, including PubMed, Embase, Web of Science, The Cochrane Library, and performed manual searches. Observational studies of relevance (cohort, case-control, or cross-sectional) published before January 13, 2025, were considered. The methodological quality of case-control studies and cohort studies was evaluated using the NOS tool. Simultaneously, AHRQ criteria were employed to evaluate cross-sectional research. The study outcomes were reported as mean ± sd. The aggregated data was analyzed using StataMP17.0.
RESULTS
A meta-analysis encompassing nine studies with 3012 participants identified a significant correlation between an increased WHtR and the onset of insulin resistance in individuals with polycystic ovarian syndrome (SMD: 1.07, 95% CI: 0.81, 1.32, p = 0.000).
CONCLUSION
Patients with PCOS and insulin resistance will exhibit a greater WHtR compared to those with PCOS without insulin resistance. Thus, the incidence of insulin resistance in patients with polycystic ovary syndrome can be anticipated by monitoring the WHtR.
SYSTEMATIC REVIEW REGISTRATION
https://www.crd.york.ac.uk/PROSPERO/view/CRD42025638798, identifier CRD42025638798.
背景
胰岛素抵抗（IR）被认为在多囊卵巢综合征（PCOS）的病理生理学中起重要作用，因此早期识别PCOS患者的IR对其治疗至关重要。最近的研究表明，与单纯PCOS患者相比，伴有IR的PCOS患者的腰高比（WHtR）有所不同；然而，尚未达成共识。本研究对现有数据进行荟萃分析，以提出一种简单的诊断伴有胰岛素抵抗的PCOS的新指标。
目的
本研究旨在通过荟萃分析和研究信息的综合，评估多囊卵巢综合征患者中WHtR与胰岛素抵抗之间的相关性。本研究将为多囊卵巢患者胰岛素抵抗的发生提供预后见解。
方法
本系统评价已在PROSPERO平台上完成注册（CRD42025638798）。我们对包括PubMed、Embase、Web of Science、Cochrane图书馆在内的著名数据库进行了检索，并进行了手动检索。纳入2025年1月13日前发表的相关观察性研究（队列研究、病例对照研究或横断面研究）。使用NOS工具评估病例对照研究和队列研究的方法学质量。同时，采用AHRQ标准评估横断面研究。研究结果以均值±标准差报告。使用StataMP17.0对汇总数据进行分析。
结果
一项纳入9项研究、3012名参与者的荟萃分析发现，多囊卵巢综合征患者中WHtR升高与胰岛素抵抗的发生之间存在显著相关性（标准化均数差：1.07，95%可信区间：0.81，1.32，p = 0.000）。
结论
与无胰岛素抵抗的PCOS患者相比，伴有胰岛素抵抗的PCOS患者将表现出更高的WHtR。因此，通过监测WHtR可以预测多囊卵巢综合征患者胰岛素抵抗的发生率。
系统评价注册
https://www.crd.york.ac.uk/PROSPERO/view/CRD42025638798，标识符CRD42025638798。
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