Guo Jie-Yu, Dong Xue-Ying, Li Shi, Tang Jing-Feng, Zhou Ce-Fan
School of Life and Health Sciences, Institute of Biomedical Research, Wuhan 430068, Hubei Province, China.
National "111" Center for Cellular Regulation and Molecular Pharmaceutics, School of Life and Health Sciences, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, Hubei Province, China.
World J Gastroenterol. 2025 Apr 14;31(14):102943. doi: 10.3748/wjg.v31.i14.102943.
Endoscopic submucosal dissection (ESD) is an effective technique for treating early esophageal cancer, and the prevention of postoperative esophageal stricture has emerged as a significant research topic. Zhou utilized an experimental minipig model to demonstrate that Kangfuxin (KFX) can improve postoperative esophageal stricture following ESD by inhibiting transforming growth factor-β1-driven fibrosis and the downstream fibrotic mediators Smad2/3. In this letter, we primarily discuss recent advancements in the treatment of esophageal stricture, the clinical applications of KFX, and the mechanisms involved in alleviating postoperative esophageal stricture, aiming to provide insights for advancing clinical practice and research in esophageal stricture after ESD.
内镜黏膜下剥离术（ESD）是治疗早期食管癌的一种有效技术，术后食管狭窄的预防已成为一个重要的研究课题。周利用实验小型猪模型证明，康复新（KFX）可通过抑制转化生长因子-β1驱动的纤维化及下游纤维化介质Smad2/3来改善ESD术后的食管狭窄。在这篇信函中，我们主要讨论食管狭窄治疗的最新进展、KFX的临床应用以及缓解术后食管狭窄的相关机制，旨在为推进ESD术后食管狭窄的临床实践和研究提供见解。
