• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一组脑膜炎球菌血清群W135感染病例系列报告

A Cluster of Meningococcal Serogroup W135 Infections: A Case Series.

作者信息

Al-Anbagi Usamah, Al Maslamani Muna, Al-Khal Abdullatif, Mohamedali Mohamed, Ahmad Muayad K, Abu Jarir Sulieman, Hamed Manal, Suby Elsa, Elshafei Moustafa S, Chikkahanasoge Ananthegowda Dore, Chaponda Mas, Al-Romaihi Hamad E, Nashwan Abdulqadir J, Aboukamar Mohamed

机构信息

Internal Medicine, Hamad Medical Corporation, Doha, QAT.

Infectious Diseases, Hamad Medical Corporation, Doha, QAT.

出版信息

Cureus. 2025 Mar 17;17(3):e80747. doi: 10.7759/cureus.80747. eCollection 2025 Mar.

DOI:10.7759/cureus.80747
PMID:40248523
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12004031/
Abstract

serogroup W135 is associated with a broad spectrum of clinical manifestations, ranging from mild localized infections to life-threatening systemic diseases. This report presents four cases of meningococcal infection in Qatar with varying presentations and complications. All patients were previously healthy, with no comorbidities, and had not received the meningococcal vaccine. All cases demonstrated elevated inflammatory markers, including C-reactive protein (CRP) and procalcitonin, and evidence of organ dysfunction, such as acute kidney injury, rhabdomyolysis, and myocarditis. Treatment with broad-spectrum antibiotics (ceftriaxone and meropenem) and aggressive supportive care, including vasopressors, mechanical ventilation, and continuous renal replacement therapy, led to gradual improvement in all patients. These cases underscore the importance of early recognition, prompt antibiotic therapy, and close monitoring of prognostic indicators, such as thrombocytopenia, elevated D-dimer, and lactate levels, in managing meningococcal disease. The variability in clinical presentations highlights the need for heightened clinical suspicion and tailored management strategies to improve outcomes in this potentially fatal condition.

摘要

W135血清群与广泛的临床表现相关，从轻度局部感染到危及生命的全身性疾病。本报告介绍了卡塔尔4例表现各异并伴有并发症的脑膜炎球菌感染病例。所有患者此前均健康，无合并症，且未接种过脑膜炎球菌疫苗。所有病例均显示炎症标志物升高，包括C反应蛋白（CRP）和降钙素原，以及器官功能障碍的证据，如急性肾损伤、横纹肌溶解和心肌炎。使用广谱抗生素（头孢曲松和美罗培南）以及积极的支持治疗，包括血管升压药、机械通气和持续肾脏替代疗法，使所有患者逐渐好转。这些病例强调了在管理脑膜炎球菌病时早期识别、及时抗生素治疗以及密切监测预后指标（如血小板减少、D-二聚体升高和乳酸水平）的重要性。临床表现的变异性凸显了提高临床怀疑度和采用针对性管理策略以改善这种潜在致命疾病预后的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/12004031/2003effcc556/cureus-0017-00000080747-i10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/12004031/968d858a76ff/cureus-0017-00000080747-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/12004031/d6486406c106/cureus-0017-00000080747-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/12004031/4a97fcb1bda2/cureus-0017-00000080747-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/12004031/231e9fad40f8/cureus-0017-00000080747-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/12004031/3e74e7ff544a/cureus-0017-00000080747-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/12004031/1940209bcf61/cureus-0017-00000080747-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/12004031/58f69c04b5ec/cureus-0017-00000080747-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/12004031/c36639c16f5b/cureus-0017-00000080747-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/12004031/086f570c4644/cureus-0017-00000080747-i09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/12004031/2003effcc556/cureus-0017-00000080747-i10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/12004031/968d858a76ff/cureus-0017-00000080747-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/12004031/d6486406c106/cureus-0017-00000080747-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/12004031/4a97fcb1bda2/cureus-0017-00000080747-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/12004031/231e9fad40f8/cureus-0017-00000080747-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/12004031/3e74e7ff544a/cureus-0017-00000080747-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/12004031/1940209bcf61/cureus-0017-00000080747-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/12004031/58f69c04b5ec/cureus-0017-00000080747-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/12004031/c36639c16f5b/cureus-0017-00000080747-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/12004031/086f570c4644/cureus-0017-00000080747-i09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/12004031/2003effcc556/cureus-0017-00000080747-i10.jpg

相似文献

1
A Cluster of Meningococcal Serogroup W135 Infections: A Case Series.一组脑膜炎球菌血清群W135感染病例系列报告
Cureus. 2025 Mar 17;17(3):e80747. doi: 10.7759/cureus.80747. eCollection 2025 Mar.
2
[Meningococcemia and meningitis due to Neisseria meningitidis W135 developed in two cases vaccinated with bivalent (A/C) meningococcal vaccine].两例接种二价（A/C）脑膜炎球菌疫苗的患者发生了由W135群脑膜炎奈瑟菌引起的脑膜炎球菌血症和脑膜炎。
Mikrobiyol Bul. 2010 Jul;44(3):473-8.
3
[Clinical characteristics and serogroup analysis of 16 pediatric cases of meningococcal meningitis].16例儿童脑膜炎球菌性脑膜炎的临床特征及血清群分析
Zhonghua Er Ke Za Zhi. 2025 Mar 2;63(3):293-297. doi: 10.3760/cma.j.cn112140-20240919-00654.
4
Pericarditis due to serogroup W135.W135血清群所致的心包炎
IDCases. 2018 Mar 7;12:53-55. doi: 10.1016/j.idcr.2018.02.009. eCollection 2018.
5
Meningococcal purpura fulminans and severe myocarditis with clinical meningitis but no meningeal inflammation: a case report.暴发性流脑紫癜合并临床脑膜炎但无脑膜炎炎症的重症心肌炎：一例报告。
BMC Infect Dis. 2019 Mar 12;19(1):252. doi: 10.1186/s12879-019-3866-x.
6
[Clinical aspects and outcome of meningococcal disease due to Neisseria meningitidis of serogroup W135 in 5 children].[5例W135群脑膜炎奈瑟菌所致脑膜炎球菌病的临床特征与转归]
Arch Pediatr. 2005 Mar;12(3):291-4. doi: 10.1016/j.arcped.2004.11.018.
7
Disease due to serogroup W135 Neisseria meningitidis.W135群脑膜炎奈瑟菌所致疾病。
Pediatrics. 1979 Aug;64(2):218-21.
8
Molecular epidemiology and emergence of worldwide epidemic clones of Neisseria meningitidis in Taiwan.台湾地区脑膜炎奈瑟菌的分子流行病学及全球流行克隆株的出现
BMC Infect Dis. 2006 Feb 15;6:25. doi: 10.1186/1471-2334-6-25.
9
[Meningococcal disease due to Neisseria meningitidis serogroup W135 in children. Clinical aspects and outcome].[儿童中由脑膜炎奈瑟菌W135血清群引起的脑膜炎球菌病。临床特征与转归]
Presse Med. 2004 Jun 5;33(10):654-7. doi: 10.1016/s0755-4982(04)98708-8.
10
Clinical features and outcome of sporadic serogroup W135 disease Taiwan.台湾散发性W135群疾病的临床特征与转归
BMC Infect Dis. 2006 Jan 19;6:7. doi: 10.1186/1471-2334-6-7.

本文引用的文献

1
Meningococcal Vaccination: Recommendations of the Advisory Committee on Immunization Practices, United States, 2020.脑膜炎球菌疫苗接种：美国免疫实践咨询委员会 2020 年的建议。
MMWR Recomm Rep. 2020 Sep 25;69(9):1-41. doi: 10.15585/mmwr.rr6909a1.
2
Meningococcal Disease Surveillance in Men Who Have Sex with Men - United States, 2015-2016.男男性行为人群中脑膜炎奈瑟菌病监测-美国，2015-2016 年。
MMWR Morb Mortal Wkly Rep. 2018 Sep 28;67(38):1060-1063. doi: 10.15585/mmwr.mm6738a4.
3
Large Outbreak of Neisseria meningitidis Serogroup C - Nigeria, December 2016-June 2017.
2016年12月至2017年6月，尼日利亚发生C群脑膜炎奈瑟菌大规模疫情。
MMWR Morb Mortal Wkly Rep. 2017 Dec 15;66(49):1352-1356. doi: 10.15585/mmwr.mm6649a3.
4
Current Epidemiology and Trends in Meningococcal Disease-United States, 1996-2015.当前脑膜炎奈瑟菌病的流行病学和趋势-美国，1996-2015 年。
Clin Infect Dis. 2018 Apr 3;66(8):1276-1281. doi: 10.1093/cid/cix993.
5
Notes from the Field: Meningococcal Disease in an International Traveler on Eculizumab Therapy - United States, 2015.现场记录：应用依库珠单抗治疗的国际旅行者感染脑膜炎奈瑟菌 - 美国，2015 年。
MMWR Morb Mortal Wkly Rep. 2016 Jul 15;65(27):696-7. doi: 10.15585/mmwr.mm6527a3.
6
Meningococcal Vaccinations.脑膜炎球菌疫苗接种。
Infect Dis Ther. 2016 Jun;5(2):89-112. doi: 10.1007/s40121-016-0107-0. Epub 2016 Apr 16.
7
Regulation of capsule in Neisseria meningitidis.脑膜炎奈瑟菌中荚膜的调控
Crit Rev Microbiol. 2016 Sep;42(5):759-72. doi: 10.3109/1040841X.2015.1022507. Epub 2015 Jun 19.
8
Hajj: infectious disease surveillance and control.朝觐：传染病监测与控制。
Lancet. 2014 Jun 14;383(9934):2073-2082. doi: 10.1016/S0140-6736(14)60381-0. Epub 2014 May 20.
9
Elevated risk for invasive meningococcal disease among persons with HIV.HIV 感染者侵袭性脑膜炎球菌病风险增加。
Ann Intern Med. 2014 Jan 7;160(1):30-7. doi: 10.7326/0003-4819-160-1-201401070-00731.
10
Prevention and control of meningococcal disease: recommendations of the Advisory Committee on Immunization Practices (ACIP).预防和控制脑膜炎球菌病：免疫实践咨询委员会（ACIP）的建议。
MMWR Recomm Rep. 2013 Mar 22;62(RR-2):1-28.