Jesiah Nicholsan, Siva Yathukulan, Mayurathan Pakkiyaretnam
University Medical Unit, Teaching Hospital Batticaloa, Batticaloa, LKA.
Department of Clinical Sciences, Faculty of Health-Care Sciences, Eastern University of Sri Lanka, Batticaloa, LKA.
Cureus. 2025 Mar 18;17(3):e80768. doi: 10.7759/cureus.80768. eCollection 2025 Mar.
Amlodipine, a calcium channel blocker of the dihydropyridine class, is frequently used to treat high blood pressure. While overdoses are rare, they can result in significant cardiovascular compromise and, infrequently, respiratory failure. We report the case of a 17-year-old male patient who presented with an intentional amlodipine overdose, and his clinical course was complicated by type 2 (hypercapnic) respiratory failure, necessitating mechanical ventilation and intensive care management. He achieved full recovery with fluid resuscitation, calcium supplementation, high-dose insulin euglycemic therapy, vasopressor support, lung-protective ventilation, and supportive therapy. This case report highlights the importance of early detection and timely management of amlodipine toxicity, which can lead to severe complications such as cardiovascular instability, fluid overload, and respiratory distress with type 2 respiratory failure.
氨氯地平是一种二氢吡啶类钙通道阻滞剂，常用于治疗高血压。虽然过量用药罕见，但可能导致严重的心血管功能损害，偶尔还会导致呼吸衰竭。我们报告一例17岁男性患者，他故意过量服用氨氯地平，其临床病程并发2型（高碳酸血症性）呼吸衰竭，需要机械通气和重症监护管理。通过液体复苏、补钙、高剂量胰岛素强化血糖治疗、血管升压药支持、肺保护性通气和支持治疗，他实现了完全康复。本病例报告强调了早期发现和及时处理氨氯地平毒性的重要性，氨氯地平毒性可导致严重并发症，如心血管不稳定、液体超负荷以及伴有2型呼吸衰竭的呼吸窘迫。
