[多哥发热患者中的亚微观物种感染]

[Submicroscopic spp. Infections in Febrile Patients in Togo].

作者信息

Teou Diwaba Carmel, Ataba Essoham, Alidou Smaila, Yakpa Kossi, Sossou Efoe, Hemou Manani, Abdou-Kerim Agueregna, Kotosso Awèréou, Bawe Lidaw Déassoua, Ménard Didier, Dorkenoo Ameyo Monique

机构信息

Faculté des sciences, Université de Lomé, Boulevard Eyadema, 01BP 1515 Lomé, Togo.

Programme national de lutte contre le paludisme, ministère de la Santé, de l'hygiène publique et de l'accès universel aux soins, Quartier administratif, 01BP 518 Lomé, Togo.

出版信息

Med Trop Sante Int. 2025 Feb 27;5(1). doi: 10.48327/mtsi.v5i1.2025.553. eCollection 2025 Mar 31.

DOI:10.48327/mtsi.v5i1.2025.553

PMID:40248575

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12001993/

Abstract

OBJECTIVE

Submicroscopic infections, mostly undetected by routine diagnostic techniques, represent a potential reservoir that contributes to the continued transmission of malaria in the community. To achieve the World Health Organization's goal of malaria elimination, it is therefore essential to identify all parasite carriers and treat them effectively with recommended antimalarial drugs. The aim of this study was to estimate the proportion of submicroscopic spp. infections not detected by microscopy in symptomatic patients with suspected malaria attending health centers in Togo, and to identify the factors associated with it.

MATERIALS AND METHODS

A cross-sectional study was conducted between September 2021 and January 2022 and between July and December 2022 in three health facilities in Togo. Each patient suspected of having malaria had a capillary blood sample taken for detection of species by thick blood film/blood smear (TBF/BS) and PCR. A logistic regression model was used to evaluate the factors linked to the parasitic results.

RESULTS

A total of 553 participants were selected, 44.6% of whom were female, with a median age of 25 years (± 2 years). The proportion of spp. infections detected by TBF/BS was 25% and by PCR 29.1%. The frequency of submicroscopic spp. infections detected by PCR in patients with negative microscopic TBF/BS was 5.5% (23/415) [95% CI: 3.7-8.2], and was the most common species (83%, 19/23, 95% CI: 60-94). Participants from the Anié and Kouvé sites were more likely to have submicroscopic infections.

CONCLUSION

This study provides preliminary data on the incidence of submicroscopic infections in Togo.

摘要

目的

亚显微感染大多无法通过常规诊断技术检测到，是社区疟疾持续传播的一个潜在源头。因此，为实现世界卫生组织的疟疾消除目标，识别所有寄生虫携带者并用推荐的抗疟药物对其进行有效治疗至关重要。本研究的目的是估计在多哥卫生中心就诊的疑似疟疾症状患者中，显微镜检查未检测到的亚显微疟原虫感染比例，并确定与之相关的因素。

材料与方法

于2021年9月至2022年1月以及2022年7月至12月在多哥的三个卫生机构开展了一项横断面研究。每名疑似疟疾患者采集一份毛细血管血样，通过厚血膜/血涂片（TBF/BS）和聚合酶链反应（PCR）检测疟原虫种类。采用逻辑回归模型评估与寄生虫检测结果相关的因素。

结果

共选取553名参与者，其中44.6%为女性，中位年龄为25岁（±2岁）。通过TBF/BS检测到的疟原虫感染比例为25%，通过PCR检测到的为29.1%。显微镜检查TBF/BS结果为阴性的患者中，通过PCR检测到的亚显微疟原虫感染频率为5.5%（23/415）[95%置信区间：3.7 - 8.2]，间日疟原虫是最常见的种类（83%，19/23，95%置信区间：60 - 94）。来自阿涅和库韦地区的参与者更易发生亚显微感染。