Tsai C H, de Leeuw N K
Acta Obstet Gynecol Scand. 1985;64(4):303-5. doi: 10.3109/00016348509155135.
In 30 non-anemic, and in 7 non-thalassemic, anemic pregnant women the red cell mass (RCM) was determined at 32-36 weeks of pregnancy, using isotopes, and was correlated with red cell 2,3-DPG, using the method of Keitt. The increase in 2,3-DPG in pregnant women with low RCM was in the same range as in those with increased RCM. Thus, 2,3-DPG can not be used to diagnose a RCM deficit in pregnancy. The relationship between 2,3-DPG and RCM in the third trimester was complex: in the 7 anemic women there was an inverse relationship, which failed to reach statistical significance, probably because of the small number of cases; in the 30 non-anemic women there was a significant, positive correlation between 2,3-DPG and RCM. The cause of this positive relationship needs further investigation.
在30名非贫血和7名非地中海贫血的贫血孕妇中，于妊娠32 - 36周使用同位素测定红细胞量（RCM），并采用基特方法将其与红细胞2,3 - 二磷酸甘油酸（2,3 - DPG）相关联。红细胞量低的孕妇中2,3 - DPG的增加幅度与红细胞量增加的孕妇相同。因此，2,3 - DPG不能用于诊断妊娠中的红细胞量不足。妊娠晚期2,3 - DPG与RCM之间的关系很复杂：在7名贫血女性中存在负相关关系，但未达到统计学意义，可能是因为病例数较少；在30名非贫血女性中，2,3 - DPG与RCM之间存在显著的正相关关系。这种正相关关系的原因需要进一步研究。
