Hayashi I, Katsuda Y, Morimatsu M, Miyamoto Y, Kiyonari H, Koga M, Nobe Y, Okumura Y, Furusawa M
Acta Pathol Jpn. 1985 Mar;35(2):507-15. doi: 10.1111/j.1440-1827.1985.tb00593.x.
A case of tubular adenoma with focal squamous metaplasia of the ascending colon in a 66-year-old male is reported. The tumor was a pedunculated polyp with a size of 1.5 X 1.4 X 0.9 cm. Histologically, the tumor showed tubular adenoma with moderate to severe atypia, was accompanied by focal squamous metaplasia. It is thought that squamous epithelial polyp may be derived from colonic adenoma with squamous metaplasia, and that the malignant change of colonic adenoma with squamous metaplasia may lead to squamous cell carcinoma, adenosquamous carcinoma, and mucoepidermoid carcinoma. Only seven cases of colonic adenoma with squamous metaplasia have been reported previously in the literature, and it is yet necessary to discuss the histogenesis, significance, and natural history of colonic adenoma with squamous metaplasia.
报告了一例66岁男性升结肠管状腺瘤伴局灶性鳞状化生的病例。肿瘤为有蒂息肉，大小为1.5×1.4×0.9厘米。组织学上，肿瘤表现为中度至重度异型性的管状腺瘤，并伴有局灶性鳞状化生。认为鳞状上皮息肉可能起源于伴有鳞状化生的结肠腺瘤，且伴有鳞状化生的结肠腺瘤的恶变可能导致鳞状细胞癌、腺鳞癌和黏液表皮样癌。此前文献中仅报道过7例伴有鳞状化生的结肠腺瘤病例，对于伴有鳞状化生的结肠腺瘤的组织发生、意义及自然史仍有必要进行讨论。
