非胰岛素依赖型糖尿病患者的血浆高密度脂蛋白胆固醇和血糖与肝脏脂质及微粒体酶活性的关系。

Plasma HDL cholesterol and blood glucose in non-insulin-dependent diabetics related to liver lipids and microsomal enzyme activity.

作者信息

Luoma P V, Savolainen M J, Sotaniemi E A, Arranto A J, Pelkonen R O

出版信息

Acta Med Scand. 1985;217(5):473-9. doi: 10.1111/j.0954-6820.1985.tb03250.x.

DOI:10.1111/j.0954-6820.1985.tb03250.x

Abstract

The major lipid predictors of coronary events, plasma high density lipoprotein cholesterol (HDL-C) and the HDL-C/total cholesterol (T-C) ratio, and blood glucose (BG) in 12 subjects with non-insulin-dependent diabetes mellitus were related to hepatic lipids, proteins and microsomal enzyme activity assessed by liver cytochrome P-450 (P-450). Non-insulin-dependent diabetics had low HDL-C/T-C ratio, liver phospholipid (PL) and P-450 and high serum and liver triglyceride (TG) concentrations. Plasma HDL-C was decreased, and BG high, especially in subjects with reduced PL and P-450. The HDL-C/T-C ratio was directly proportional to liver PL and P-450 and unrelated to hepatic TG. Increases in liver PL and microsomal enzyme activity may be favorably reflected both in cholesterol distribution and diabetic control.

摘要

在12名非胰岛素依赖型糖尿病患者中，冠心病事件的主要脂质预测指标——血浆高密度脂蛋白胆固醇（HDL-C）、HDL-C/总胆固醇（T-C）比值以及血糖（BG），与通过肝细胞色素P-450（P-450）评估的肝脏脂质、蛋白质和微粒体酶活性相关。非胰岛素依赖型糖尿病患者的HDL-C/T-C比值、肝脏磷脂（PL）和P-450较低，血清和肝脏甘油三酯（TG）浓度较高。血浆HDL-C降低，BG升高，尤其是在PL和P-450降低的患者中。HDL-C/T-C比值与肝脏PL和P-450成正比，与肝脏TG无关。肝脏PL和微粒体酶活性的增加可能在胆固醇分布和糖尿病控制方面都得到有利反映。