Laser treatment of cervical intraepithelial neoplasia in an office setting.

One hundred eighty-six patients underwent carbon dioxide laser treatment of cervical intraepithelial neoplasia. Both vaporization and excisional procedures were performed in an office setting without difficulty. Thirty-nine patients (36.4%) had grade 1, 38 (35.6%) had grade 2, and 30 (28%) had grade 3. Among 107 patients followed up for at least 6 months, there were two treatment failures (5.1%) in the grade 1 group and no treatment failures for grades 2 and 3. The overall success rate for all grades of cervical intraepithelial neoplasia was 98% for a single laser treatment. Our ability to use the laser to excise a specimen, as well as to treat large and endocervical lesions, allowed the office treatment of many patients who would otherwise have required hospitalization.