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不同孕产妇年龄组妊娠风险的比较研究。

Comparative study of pregnancy risks in different maternal age groups.

作者信息

Sunder Amala, Khaled Hadi Yusuf, Alkhuzaei Noor Ammar, Jamal Bushaqer Nayla, Al Khalifa Haya Isa, Darwish Basma, Dayoub Nawal

机构信息

From the Department of Obstetrics & Gynecology (Sunder, Bushaqer, Al khalifa,Darwish), Bahrain Defense Force Hospital, Riffa, Bahrain; (Hadi, Alkhuzaei), Royal College of Surgeons in Ireland, Busaiteen, and (Dayoub), Assisted Reproductive and Gynecology Centre, London.

出版信息

Saudi Med J. 2025 Apr;46(4):378-387. doi: 10.15537/smj.2025.46.4.20240555.

Abstract

OBJECTIVES

To evaluate and compare pregnancy complications associated with varying maternal age groups.

METHODS

A retrospective analysis of singleton pregnancy outcomes at Bahrain Defense Force Hospital from January to December 2022. The study population was divided into 4 age groups: <25 years, 25-29 years, 30-34 years, and ≥35 years. Data on demographics, maternal and fetal characteristics were collected, and statistical significance was set at <0.05. Univariate logistic regression was performed to analyze maternal and neonatal outcomes, adjusting for maternal factors.

RESULTS

The study included 2,972 women aged 17-55. Significant associations were found between maternal age and outcomes. Body mass index (BMI) was significantly linked to age (<0.01), with younger women having lower BMI. Gestational diabetes mellitus (GDM) was more common in women ≥35 years (11.5%) vs. those <25 years (6.6%, =0.027). Intrauterine growth restriction (IUGR) was more prevalent in the <25 years age group (=0.041).Logistic regression showed women 30-34 years had a lower risk of GDM compared to 25-29 years (odds ratio [OR]: 0.544, CI: 0.365-0.811), and women <25 years had a higher risk of preterm delivery (OR: 1.365, CI: 1.015-1.837).

CONCLUSION

Maternal age is an independent risk factor for various adverse outcomes. Younger women (<25) are at higher risk for preterm delivery and IUGR, while older women (≥35) have higher rates of GDM.

摘要

目的

评估和比较不同孕产妇年龄组相关的妊娠并发症。

方法

对2022年1月至12月在巴林国防军医院的单胎妊娠结局进行回顾性分析。研究人群分为4个年龄组:<25岁、25 - 29岁、30 - 34岁和≥35岁。收集了人口统计学、孕产妇和胎儿特征的数据,统计学显著性设定为<0.05。进行单因素逻辑回归分析孕产妇和新生儿结局,并对孕产妇因素进行校正。

结果

该研究纳入了2972名年龄在17 - 55岁之间的女性。发现孕产妇年龄与结局之间存在显著关联。体重指数(BMI)与年龄显著相关(<0.01),年轻女性的BMI较低。妊娠糖尿病(GDM)在≥35岁的女性中更常见(11.5%),而在<25岁的女性中为6.6%(P = 0.027)。小于胎龄儿(IUGR)在<25岁年龄组中更普遍(P = 0.041)。逻辑回归显示,30 - 34岁的女性患GDM的风险低于25 - 29岁的女性(优势比[OR]:0.544,置信区间[CI]:0.365 - 0.811),<25岁的女性早产风险更高(OR:1.365,CI:1.015 - 1.837)。

结论

孕产妇年龄是各种不良结局的独立危险因素。年轻女性(<25岁)早产和IUGR风险较高,而年长女性(≥35岁)GDM发生率较高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9929/12010492/41ad9c12fb05/smj-46-4-378_1.jpg

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