Xu Yao, Gao Zhaoyu, Liu Jiaying, Yang Qianqian, Xu Shunjiang
Central Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, P. R. China.
Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, P. R. China.
Gut Microbes. 2025 Dec;17(1):2495183. doi: 10.1080/19490976.2025.2495183. Epub 2025 Apr 20.
The pathogenesis of cancer is closely related to the disruption of homeostasis in the human body. The gut microbiome plays crucial roles in maintaining the homeostasis of its host throughout lifespan. In recent years, a large number of studies have shown that dysbiosis of the gut microbiome is involved in the entire process of cancer initiation, development, and prognosis by influencing the host immune system and metabolism. Some specific intestinal bacteria promote the occurrence and development of cancers under certain conditions. Conversely, some other specific intestinal bacteria suppress the oncogenesis and progression of cancers, including inhibiting the occurrence of cancers, delaying the progression of cancers and boosting the therapeutic effect on cancers. The promoting effects of the gut microbiome on cancers have been comprehensively discussed in the previous review. This article will review the latest advances in the roles and mechanisms of gut microbiome in cancer suppression, providing a new perspective for developing strategies of cancer prevention and treatment.
癌症的发病机制与人体体内稳态的破坏密切相关。肠道微生物群在宿主的整个生命周期中对维持其体内稳态起着至关重要的作用。近年来，大量研究表明，肠道微生物群的失调通过影响宿主免疫系统和新陈代谢，参与了癌症发生、发展和预后的全过程。某些特定的肠道细菌在特定条件下会促进癌症的发生和发展。相反，其他一些特定的肠道细菌则会抑制癌症的发生和进展，包括抑制癌症的发生、延缓癌症的进展以及增强对癌症的治疗效果。肠道微生物群对癌症的促进作用已在前一篇综述中进行了全面讨论。本文将综述肠道微生物群在癌症抑制中的作用及机制的最新进展，为制定癌症预防和治疗策略提供新的视角。
