Yang Yanguang, Shi Xinli
Laboratory of Integrated Medicine Tumor Immunology, Shanxi University of Chinese Medicine, Taiyuan, China.
Department of Pathobiology and Immunology, Hebei University of Chinese Medicine, Shijiazhuang, China.
Front Immunol. 2025 Feb 14;16:1524563. doi: 10.3389/fimmu.2025.1524563. eCollection 2025.
Hepatocellular carcinoma (HCC) is the most frequently occurring type of liver tumor and is considered one of the most common primary malignant neoplasms. The prognosis for HCC is dismal because of its complicated etiology and high level of medication resistance. Immunotherapy is presently regarded as one of the most effective therapeutic options for HCC; nevertheless, because of the disturbance of intestinal flora, immunotherapy shows low antitumor efficacy. An increasing body of research indicates that intestinal flora, particularly (), is vital for the treatment of tumors. Studies have demonstrated that the diminished effectiveness of immunotherapy in cancer patients is associated with a reduction in levels, suggesting that increasing levels significantly enhance the efficacy of immunotherapy. functions as a gut probiotic and can treat and prevent a wide range of illnesses, including cancer. Consequently, preserving abundance is enough to prevent and lower the danger of developing cancer disorders. In this review, we critically evaluate the current body of research on , with a primary focus on its biological properties and functions. The different illnesses that treats were then discussed, particularly the way it works with liver cancer. This review aims to give a novel treatment plan for patients with HCC as well as a theoretical foundation for improving HCC immunotherapy.
肝细胞癌（HCC）是最常见的肝脏肿瘤类型，被认为是最常见的原发性恶性肿瘤之一。由于其病因复杂且耐药性高，HCC的预后很差。免疫疗法目前被认为是治疗HCC最有效的治疗选择之一；然而，由于肠道菌群的紊乱，免疫疗法显示出较低的抗肿瘤疗效。越来越多的研究表明，肠道菌群，特别是（），对肿瘤治疗至关重要。研究表明，癌症患者免疫疗法有效性的降低与（）水平的降低有关，这表明提高（）水平可显著增强免疫疗法的疗效。（）作为一种肠道益生菌，可以治疗和预防包括癌症在内的多种疾病。因此，保持（）的丰度足以预防和降低患癌症疾病的风险。在这篇综述中，我们批判性地评估了当前关于（）的研究现状，主要关注其生物学特性和功能。然后讨论了（）治疗的不同疾病，特别是它与肝癌的作用方式。这篇综述旨在为HCC患者提供一种新的治疗方案，并为改善HCC免疫疗法提供理论基础。
