脉搏波速度与阿尔茨海默病脑脊液生物标志物之间的关联。
The association between pulse wave velocity and cerebrospinal fluid biomarkers for Alzheimer's disease.
作者信息
Kim Hyena, Kulshreshtha Ambar, Alonso Alvaro, Goldstein Felicia C, Johnson Erik Cb, Gold Matthew E, Quyyumi Arshed A, Lah James J
机构信息
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Department of Family and Preventive Medicine, Emory School of Medicine, Atlanta, GA, USA.
出版信息
J Alzheimers Dis. 2025 Jun;105(3):729-735. doi: 10.1177/13872877251331235. Epub 2025 Apr 21.
We examined the association between arterial stiffness using non-invasive pulse wave velocity (PWV) and cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers. We conducted a cross-sectional multivariate logistic regression analysis using established cut-off values for PWV and CSF biomarkers. Of the 739 participants, 69% were female, 84% were White, 12% were Black, and the mean age was 62. After adjustment for potential confounders, participants with high PWV had 94% (OR = 1.94, 95% CI 1.20-3.20) greater odds of AD biomarker positivity for tTau/Aβ and 108% (OR = 2.08, 95% Cl, 1.27-3.46) for pTau181/Aβ. Our results suggest that higher arterial stiffness is associated with AD CSF biomarker positivity.
我们研究了使用无创脉搏波速度（PWV）测量的动脉僵硬度与脑脊液（CSF）阿尔茨海默病（AD）生物标志物之间的关联。我们使用PWV和CSF生物标志物的既定临界值进行了横断面多变量逻辑回归分析。在739名参与者中，69%为女性，84%为白人，12%为黑人，平均年龄为62岁。在对潜在混杂因素进行调整后，PWV较高的参与者中tTau/Aβ的AD生物标志物阳性几率高94%（OR = 1.94，95%CI 1.20 - 3.20），pTau181/Aβ的阳性几率高108%（OR = 2.08，95%Cl，1.27 - 3.46）。我们的结果表明，较高的动脉僵硬度与AD脑脊液生物标志物阳性有关。
Zotero 插件