Edwards Lauren, Smirnov Denis S, Thomas Kelsey R, Longardner Katherine, Delano-Wood Lisa, Bondi Mark W, Salmon David P, Galasko Douglas, Bangen Katherine J
San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California, USA.
Department of Neurosciences, University of California, San Diego, La Jolla, California, USA.
Alzheimers Dement. 2025 Sep;21(9):e70632. doi: 10.1002/alz.70632.
Among individuals who are amyloid biomarker-positive or apolipoprotein E (APOE) ε4 carriers, arterial stiffness reflected by higher pulse wave velocity (PWV) has been associated with lower cognition cross-sectionally. Less is known about longitudinal associations.
The sample included 152 older adults without dementia. Linear mixed-effects models examined if PWV (1) was associated with cognitive decline and (2) interacted with APOE ɛ4 status or cerebrospinal fluid (CSF) amyloid positivity on cognitive decline.
PWV was not associated with cognitive decline across any domains. There was an interaction between PWV and CSF amyloid positivity on executive function (p = 0.038) and language (p = 0.047), such that higher PWV was related to faster decline in CSF amyloid-positive individuals relative to amyloid-negative individuals. PWV did not interact with APOE ɛ4 status on cognitive decline.
PVW, as a marker of vascular risk, may adversely modify the trajectory of cognitive decline, particularly in amyloid-positive individuals.
Pulse wave velocity (PWV) was not associated with cognitive decline in any domain. Amyloid status moderated the effect of PWV on executive function and language decline. Higher PWV was associated with faster decline among amyloid-positive individuals. There was no interaction between PWV and apolipoprotein E (APOE) ε4 status on cognitive decline.
在淀粉样蛋白生物标志物呈阳性或载脂蛋白E（APOE）ε4携带者中，较高脉搏波速度（PWV）所反映的动脉僵硬度与较低的横断面认知水平相关。关于纵向关联的了解较少。
样本包括152名无痴呆的老年人。线性混合效应模型检验了PWV（1）是否与认知衰退相关，以及（2）是否与APOE ε4状态或脑脊液（CSF）淀粉样蛋白阳性在认知衰退方面存在交互作用。
PWV在任何领域均与认知衰退无关。PWV与CSF淀粉样蛋白阳性在执行功能（p = 0.038）和语言（p = 0.047）方面存在交互作用，相对于淀粉样蛋白阴性个体，较高的PWV与CSF淀粉样蛋白阳性个体更快的衰退相关。PWV与认知衰退方面的APOE ε4状态不存在交互作用。
作为血管风险标志物的PWV可能会对认知衰退轨迹产生不利影响，尤其是在淀粉样蛋白阳性个体中。
脉搏波速度（PWV）在任何领域均与认知衰退无关。淀粉样蛋白状态调节了PWV对执行功能和语言衰退的影响。较高的PWV与淀粉样蛋白阳性个体更快的衰退相关。PWV与载脂蛋白E（APOE）ε4状态在认知衰退方面不存在交互作用。
