Sohail Muhammad Umer, Aisha Eliza, Waqas Saad Ahmed, Saad Muhammad, Arshad Muhammad Sameer, Ahmed Aymen, Sohail Muhammad Ovais, Naveed Zara, Amin Emaan, Arora Sahej, Jawaid Hafsa, Jain Aakriti, Memon Muhammad Mustafa
Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
Department of Medicine, Conemaugh Memorial Medical Center, Johnstown, PA, USA.
Future Cardiol. 2025 Jun;21(7):479-487. doi: 10.1080/14796678.2025.2490397. Epub 2025 Apr 21.
Obesity is a critical risk factor for ischemic heart disease (IHD), affecting 42% of the U.S. population. This study examines trends in obesity-related IHD mortality among U.S. adults aged 25 and older from 1999 to 2020, using the CDC WONDER database.
We analyzed IHD as the primary cause and obesity as a contributing factor, calculating age-adjusted (AAMRs) and crude mortality rates (CMRs) per 100,000 individuals. Joinpoint regression assessed annual percent changes (APC), stratifying by race, sex, age, and region.
From 1999 to 2020, 139,644 obesity-related IHD deaths were recorded. AAMR rose from 1.92 to 4.69 per 100,000. Rates were higher in men (3.79) than women (2.10), with Black Americans showing the highest AAMR (4.07). Older adults (65+) had the highest CMR (5.73). Nonmetropolitan areas exhibited higher AAMRs (3.47) than metropolitan regions (2.78). States with the highest mortality included Vermont, Oklahoma, Wyoming, Wisconsin and Iowa while Alabama, Virginia, Massachusetts, Connecticut and Georgia had the lowest.
The findings indicate a 2.5-fold increase in obesity-related IHD mortality, highlighting the need for targeted public health interventions and further research to address this growing public health concern.
肥胖是缺血性心脏病（IHD）的一个关键风险因素，影响着42%的美国人口。本研究使用美国疾病控制与预防中心（CDC）的WONDER数据库，调查了1999年至2020年美国25岁及以上成年人中与肥胖相关的IHD死亡率趋势。
我们将IHD作为主要病因，肥胖作为一个促成因素进行分析，计算每10万人的年龄调整死亡率（AAMRs）和粗死亡率（CMRs）。Joinpoint回归评估年度百分比变化（APC），并按种族、性别、年龄和地区进行分层。
1999年至2020年期间，共记录了139,644例与肥胖相关的IHD死亡病例。AAMR从每10万人1.92例上升至4.69例。男性（3.79例）的死亡率高于女性（2.10例），非裔美国人的AAMR最高（4.07例）。老年人（65岁及以上）的CMR最高（5.73例）。非都市地区的AAMR（3.47例）高于都市地区（2.78例）。死亡率最高的州包括佛蒙特州、俄克拉何马州、怀俄明州、威斯康星州和爱荷华州，而阿拉巴马州、弗吉尼亚州、马萨诸塞州、康涅狄格州和佐治亚州的死亡率最低。
研究结果表明，与肥胖相关的IHD死亡率增加了2.5倍，凸显了有针对性的公共卫生干预措施以及进一步研究以应对这一日益严重的公共卫生问题的必要性。
