Lechner R B, Gurll N J, Reynolds D G
Am J Physiol. 1985 Aug;249(2 Pt 2):H272-7. doi: 10.1152/ajpheart.1985.249.2.H272.
Treatment with naloxone improves cardiovascular function and survival in a variety of shock models, and numerous sites and mechanisms for its action have been proposed. Data presented in this article support the hypothesis that in hemorrhagic shock naloxone exerts its beneficial hemodynamic effects by acting primarily at cardiac opiate receptors. Naloxone or its stereoisomer (d-naloxone) were administered intravenously (iv) and directly into the coronary circulation (ic) in dogs anesthetized with pentobarbital sodium and subjected to hemorrhagic shock. Treatment with naloxone (2.0 mg/kg iv or 0.2 mg/kg ic) resulted in significant improvements in arterial pressure, myocardial contractility, and cardiac output. Treatment with saline or naloxone (0.2 mg/kg iv) were without beneficial effect. The hemodynamic responses to naloxone administered into the coronary circulation were dose dependent and stereospecific. These data support the hypothesis that naloxone exerts its salubrious effects in canine hemorrhagic shock by acting at cardiac opiate receptors.
在多种休克模型中，使用纳洛酮进行治疗可改善心血管功能并提高生存率，人们已提出了其作用的众多部位和机制。本文所呈现的数据支持这样一种假说，即在失血性休克中，纳洛酮主要通过作用于心脏阿片受体发挥有益的血液动力学效应。在戊巴比妥钠麻醉并遭受失血性休克的犬中，静脉内（iv）和直接经冠状动脉循环（ic）给予纳洛酮或其立体异构体（d - 纳洛酮）。用纳洛酮（2.0毫克/千克静脉注射或0.2毫克/千克冠状动脉内注射）治疗可显著改善动脉压、心肌收缩力和心输出量。用生理盐水或纳洛酮（0.2毫克/千克静脉注射）治疗则无有益效果。经冠状动脉循环给予纳洛酮后的血液动力学反应呈剂量依赖性且具有立体特异性。这些数据支持这样的假说，即纳洛酮通过作用于心脏阿片受体在犬失血性休克中发挥有益作用。
