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伴有瘤内出血的顶盖胶质瘤

Tectal Plate Glioma Presenting With Intratumoral Hemorrhage.

作者信息

Passman Justin N, Singh Heshwin, Razzaq Bayan, Mikell Charles B, Chesler David A

机构信息

Neurological Surgery, Renaissance School of Medicine at Stony Brook University, Stony Brook, USA.

Neurosurgery, Stony Brook University, Stony Brook, USA.

出版信息

Cureus. 2025 Mar 19;17(3):e80813. doi: 10.7759/cureus.80813. eCollection 2025 Mar.

Abstract

Tectal gliomas are rare brainstem tumors. These tumors typically cause obstructive hydrocephalus due to mass effect on the cerebral aqueduct; however, intratumoral hemorrhage is exceedingly rare, with only one previously documented case to our knowledge. Patients typically present with symptoms of hydrocephalus, including headaches, nausea, and visual disturbances. We report the case of a 43-year-old man with a known tectal plate glioma who presented with acute obstructive hydrocephalus secondary to intratumoral hemorrhage. Following the patient's rapid neurological decline, computed tomography (CT) and magnetic resonance imaging (MRI) confirmed the diagnosis. The patient underwent an endoscopic third ventriculocisternostomy (ETV) for cerebrospinal fluid diversion, along with an endoscopic biopsy of the tectal mass. The patient's postoperative course was favorable, with gradual resolution of symptoms, including diplopia and headaches. A follow-up MRI revealed reduced tumor size and stable ventriculomegaly. Histopathological analysis suggested the tumor to be of glial origin and low-grade in nature, based on its contrast enhancement on MRI and the patient's clinical trajectory. This case illustrates a rare presentation of intratumoral hemorrhage in tectal gliomas, emphasizing the need for heightened clinical suspicion in such cases. ETV remains an effective treatment for obstructive hydrocephalus, though the potential for hemorrhagic complications warrants close monitoring.

摘要

顶盖胶质瘤是罕见的脑干肿瘤。这些肿瘤通常由于对大脑导水管的占位效应而导致梗阻性脑积水;然而,肿瘤内出血极为罕见,据我们所知此前仅有一例记录在案。患者通常表现出脑积水的症状,包括头痛、恶心和视觉障碍。我们报告一例43岁男性病例,该患者已知患有顶盖胶质瘤,因肿瘤内出血继发急性梗阻性脑积水。在患者神经功能迅速衰退后,计算机断层扫描(CT)和磁共振成像(MRI)确诊了病情。该患者接受了内镜下第三脑室造瘘术(ETV)以进行脑脊液分流,并对顶盖肿物进行了内镜活检。患者术后恢复良好,包括复视和头痛在内的症状逐渐缓解。随访MRI显示肿瘤大小减小,脑室扩大稳定。基于MRI上的对比增强以及患者的临床病程,组织病理学分析提示该肿瘤起源于神经胶质且为低级别。本病例说明了顶盖胶质瘤中肿瘤内出血的罕见表现,强调在此类病例中需要提高临床怀疑度。ETV仍然是治疗梗阻性脑积水的有效方法,尽管出血性并发症的可能性需要密切监测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b240/12007068/5bb33c4edc2b/cureus-0017-00000080813-i01.jpg

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