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顶盖胶质瘤综述

Tectal plate gliomas: a review.

作者信息

Igboechi Chiazor, Vaddiparti Aparna, Sorenson Edward P, Rozzelle Curtis J, Tubbs R Shane, Loukas Marios

机构信息

Department of Anatomical Sciences, School of Medicine, St. George's University, St. George, Grenada, West Indies.

出版信息

Childs Nerv Syst. 2013 Oct;29(10):1827-33. doi: 10.1007/s00381-013-2110-z. Epub 2013 Apr 24.

Abstract

INTRODUCTION

Tectal plate gliomas are generally benign neoplastic lesions arising in the brainstem which can, with local extension, obstruct the aqueduct of Sylvius and lead to hydrocephalus.

ANATOMY

Diagnosis is based on initial suspicion fostered by the presentation of an obstructive hydrocephalus followed by physical exam which may potentially reveal indications of pyramidal tract dysfunction or cranial nerve palsies.

DISCUSSION

MRI studies reveal a characteristic well-circumscribed, isodense or hypodense mass on T1-weighted images, with hyperdensity on T2 imaging. Yet current radiological methods insufficiently distinguish tectal plate gliomas from brainstem tumors or gliomas in the neighboring structures, and a definitive diagnosis requires biopsy and histopathological analysis. Management is planned according to the degree of associated signs and symptoms, and may range from diligent observation and periodic screening for advancing tumor development, to cerebrospinal fluid shunting in an effort to resolve obstructive hydrocephalus, to radio- and chemotherapy. A wide range of minimally invasive approaches using endoscopy is available for the neurosurgeon, including endoscopic third ventriculostomy and endoscopic aqueductoplasty.

摘要

引言

顶盖胶质瘤通常是起源于脑干的良性肿瘤性病变,可通过局部扩展阻塞中脑导水管并导致脑积水。

解剖学

诊断基于因阻塞性脑积水的表现而产生的初步怀疑,随后进行体格检查,体格检查可能会揭示锥体束功能障碍或颅神经麻痹的迹象。

讨论

磁共振成像(MRI)研究显示,在T1加权图像上有一个边界清晰、等密度或低密度的特征性肿块,在T2成像上呈高密度。然而,目前的放射学方法不足以将顶盖胶质瘤与脑干肿瘤或邻近结构中的胶质瘤区分开来,明确诊断需要活检和组织病理学分析。治疗方案根据相关体征和症状的程度制定,范围可能从密切观察和定期筛查肿瘤进展,到进行脑脊液分流以解决阻塞性脑积水,再到放疗和化疗。神经外科医生有多种使用内镜的微创方法可供选择,包括内镜下第三脑室造瘘术和内镜下导水管成形术。

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