Essadiqi Soukaina, Bahlaoui Omar, Nadi Anass, Khannoussi Wafaa, Ben El Barhdadi Imane
Mohammed VI Faculty of Medicine, Mohammed VI University of Sciences and Health, Casablanca, MAR.
Gastroenterology Department, Cheikh Khalifa International University Hospital, Casablanca, MAR.
Cureus. 2025 Mar 21;17(3):e80970. doi: 10.7759/cureus.80970. eCollection 2025 Mar.
Acute esophageal necrosis is a rare (0.01%) and life-threatening condition (5% specific-mortality) involving blackening of the esophagus mucosa resulting from a combination of ischemic damage and gastric acid reflux, although the exact pathophysiology is still unclear. A 70-year-old female patient was admitted to the intensive care unit following two episodes of hematemesis. Her medical history included diabetes mellitus and ischemic heart disease. At admission an inaugural complete atrial fibrillation was discovered on electrocardiogram. Biological and bacteriological tests revealed urinary tract infection. An esophageo-gastro-duodenoscopy showed typical blackening of the lower third of the esophagus. Treatment consisted of intravenous fluids, high-dose proton pump inhibitors, nothing through the mouth status and intravenous antibiotic therapy. Repeat esophageo-gastro-duodenoscopy showed significant improvement. However, her condition deteriorated as she succumbed to septic shock. Our patient presented with negative prognostic factors like advanced age, diabetes mellitus, ischemic heart disease and inaugural arrhythmia that may have contributed to the development of acute esophageal necrosis.
急性食管坏死是一种罕见(0.01%)且危及生命的疾病(特异性死亡率为5%),其特征为食管黏膜发黑,由缺血性损伤和胃酸反流共同作用所致,尽管确切的病理生理学机制仍不清楚。一名70岁女性患者因两次呕血被收入重症监护病房。她的病史包括糖尿病和缺血性心脏病。入院时心电图发现初发性完全性心房颤动。生物学和细菌学检查显示存在尿路感染。食管胃十二指肠镜检查显示食管下三分之一处有典型的发黑。治疗包括静脉输液、大剂量质子泵抑制剂、禁食和静脉抗生素治疗。重复食管胃十二指肠镜检查显示有显著改善。然而,她的病情恶化,最终死于感染性休克。我们的患者存在如高龄、糖尿病、缺血性心脏病和初发性心律失常等不良预后因素,这些因素可能促成了急性食管坏死的发生。