ABO血型与子痫前期风险。一项病例对照研究。
ABO blood group and risk of pre-eclampsia. A case-control study.
作者信息
Bezanahary Holy, Thiolon Jonathan, Dalmay François, Eyraud Jean-Luc, Youssef Baher, Aubard Yves, Lacroix Philippe, Chastaingt Lucie, Coste-Mazeau Perrine
机构信息
Inserm, U1094, EpiMaCT - Epidemiology of chronic diseases in tropical zone, Limoges, France.
IRD, U270, EpiMaCT - Epidemiology of chronic diseases in tropical zone, Limoges, France.
出版信息
Obstet Med. 2025 Apr 18:1753495X251333629. doi: 10.1177/1753495X251333629.
BACKGROUND
It appears that some ABO blood groups may be a risk factor for venous thrombosis. The association between ABO group and risk of pre-eclampsia remains controversial. The purpose of this study was to evaluate the relationship between pre-eclampsia and ABO groups.
METHODS
A retrospective case-control (1:2) study in a prospective monocentric registry including 20171 pregnancies was performed. Women with pre-eclampsia and severe pre-eclampsia were identified. Controls were matched according to age, parity, year of delivery and body mass index. Blood groups were considered.
RESULTS
Two hundred fifty-three cases and 506 controls were included. No difference in distribution was found between cases and controls for non-O group (57.51% vs 62.56, : 0.19), group A (39.92% vs 44.05, : 0.29), group B (13.83% vs 15.42, : 0.57) group AB (3.75 vs 3.08, : 0.64). The analysis extended to severe pre-eclampsia showed no difference.
CONCLUSION
This study did not document any relationship between ABO groups and the risk of preeclampsia.
背景
某些ABO血型似乎可能是静脉血栓形成的危险因素。ABO血型与子痫前期风险之间的关联仍存在争议。本研究的目的是评估子痫前期与ABO血型之间的关系。
方法
在一个前瞻性单中心登记处进行了一项回顾性病例对照（1:2）研究，该登记处包括20171例妊娠。确定患有子痫前期和重度子痫前期的女性。根据年龄、产次、分娩年份和体重指数匹配对照组。考虑血型。
结果
纳入253例病例和506例对照。非O组（57.51%对62.56%，P = 0.19）、A组（39.92%对44.05%，P = 0.29）、B组（13.83%对15.42%，P = 0.57）、AB组（3.75%对3.08%，P = 0.64）的病例组和对照组之间分布无差异。扩展至重度子痫前期的分析也无差异。
结论
本研究未证明ABO血型与子痫前期风险之间存在任何关系。
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