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复发性多软骨炎合并甲状腺癌:马达加斯加首例病例

Relapsing Polychondritis Associated With Thyroid Carcinoma: A First Malagasy Case.

作者信息

Rakotonirainy Oliva Henintsoa, Andrianiaina Mamonjisoa Olivier, Rakotonirina Lalao Nomenjanahary, Ratovonjanahary Volatantely, Rabenja Rapelanoro Fahafahantsoa

机构信息

Department of Rheumatology and Dermatology, Joseph Raseta Befelatanana University Hospital, Antananarivo, Madagascar.

Department of Internal Medicine, Joseph Raseta Befelatanana University Hospital, Antananarivo, Madagascar.

出版信息

Case Rep Otolaryngol. 2025 Apr 11;2025:1456640. doi: 10.1155/crot/1456640. eCollection 2025.

Abstract

Relapsing polychondritis (RP) is a rare disease characterized by recurrent systemic inflammation affecting cartilaginous tissues and proteoglycan-rich tissues. The disease may present in several clinical variants, which can delay diagnosis. Corticosteroids are the treatment of choice for RP. In rare cases, RP can be paraneoplastic. The association of RP with thyroid cancer is unusual. We report the first Malagasy case of a 48-year-old man with RP type one diagnosed within less than a year, presenting with recurrent chondritis of the auricular cartilage, tracheobronchial chondritis, and recurrent episcleritis. The disease was associated with papillary thyroid carcinoma.

摘要

复发性多软骨炎(RP)是一种罕见疾病,其特征为影响软骨组织和富含蛋白聚糖组织的反复全身性炎症。该疾病可能以多种临床变体形式出现,这可能会延迟诊断。皮质类固醇是RP的首选治疗方法。在罕见情况下,RP可能是副肿瘤性的。RP与甲状腺癌的关联并不常见。我们报告了马达加斯加的首例病例,一名48岁男性在不到一年的时间内被诊断为1型RP,表现为耳廓软骨反复性软骨炎、气管支气管软骨炎和反复性巩膜炎。该疾病与乳头状甲状腺癌相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5a5/12008485/bc48ce75aace/CRIOT2025-1456640.001.jpg

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