手性杂化磁性聚合物颗粒上的对映选择性结晶

Moshe Yarden Ben, Abuaf Meir, Mordechai Chen, Sharoni Amos, Mastai Yitzhak

Department of Chemistry, Bar-Ilan University, Ramat Gan 5900002, Israel.

Bar-Ilan Institute of Nanotechnology and Advanced Materials (BINA), Bar-Ilan University, Ramat Gan 5900002, Israel.

ACS Omega. 2025 Apr 1;10(14):14075-14083. doi: 10.1021/acsomega.4c11154. eCollection 2025 Apr 15.

A new class of Janus chiral magnetic polymeric particles was fabricated for chiral resolution by enantioselective crystallization. -Acryloyl-l/d-Phe methyl ester beads were prepared with controlled sizes and coated with ferromagnetic permalloy. Chiral discrimination by enantiopure d-Ala crystals was investigated in a model for racemic crystallization. X-ray diffraction and differential scanning calorimetry support the crystallization of the particles. Analysis of optical rotation reveals a d-Ala enantiomeric excess of about 11%, effectively establishing the concept of chiral discrimination by enantioselective crystallization on these Janus chiral magnetic polymeric particles.

通过对映选择性结晶制备了一类新型的Janus手性磁性聚合物颗粒用于手性拆分。制备了尺寸可控的 -丙烯酰基-l/d-苯丙氨酸甲酯珠粒，并涂覆铁磁坡莫合金。在消旋结晶模型中研究了对映纯d-丙氨酸晶体的手性识别。X射线衍射和差示扫描量热法支持颗粒的结晶。旋光分析显示d-丙氨酸对映体过量约为11%，有效地确立了在这些Janus手性磁性聚合物颗粒上通过对映选择性结晶进行手性识别的概念。