Chen Michele, Deck Leif-Thore, Bosetti Luca, Mazzotti Marco
Institute of Energy and Process Engineering, ETH Zürich, 8092 Zürich, Switzerland.
Cryst Growth Des. 2025 Apr 4;25(8):2498-2509. doi: 10.1021/acs.cgd.4c01722. eCollection 2025 Apr 16.
Understanding nucleation kinetics is vital for designing crystallization processes, yet traditional measurement methods based on cooling are unsuitable for compounds with temperature-independent solubility. This study introduces an experimental procedure to measure the nucleation kinetics based on evaporative crystallization and applies it to sodium chloride (NaCl) in water. By systematically varying the experimental conditions such as temperature and evaporation gas flow rate, we obtained a comprehensive data set for the nucleation of NaCl crystals that allowed estimating kinetic parameters using a rate expression derived from classical nucleation theory (CNT). This work demonstrates the robustness of evaporation as a method for measuring the nucleation kinetics that is applicable regardless of how the solubility of a compound depends on the temperature.
理解成核动力学对于设计结晶过程至关重要，但基于冷却的传统测量方法不适用于溶解度与温度无关的化合物。本研究介绍了一种基于蒸发结晶测量成核动力学的实验程序，并将其应用于水中的氯化钠（NaCl）。通过系统地改变温度和蒸发气体流速等实验条件，我们获得了一套关于NaCl晶体成核的综合数据集，从而能够使用从经典成核理论（CNT）推导的速率表达式来估计动力学参数。这项工作证明了蒸发作为一种测量成核动力学方法的稳健性，该方法适用于任何化合物的溶解度如何随温度变化的情况。
