改进美国国立卫生研究院资助的涉及行为干预的临床试验中所使用的设计和分析方法。
Improving the design and analytic methods used in NIH-funded clinical trials involving behavioral interventions.
作者信息
Murray David M, Simoni Jane M
机构信息
Associate Director for Prevention, Director, Office of Disease Prevention, National Institutes of Health, 6705 Rockledge Drive, Room 734B, Bethesda, MD 20892, United States.
Associate Director for Behavioral and Social Sciences Research, Director, Office of Behavioral and Social Sciences Research, National Institutes of Health, 31 Center Drive, Building 31, Room B1C19, Bethesda, MD 20892, United States.
出版信息
Ann Behav Med. 2025 Jan 4;59(1). doi: 10.1093/abm/kaaf026.
Behavioral interventions are widely used in clinical trials supported by the National Institutes of Health (NIH). When behavioral interventions involve group-formatted components and/or shared interventionists, they require special design and analytic methods not needed in trials that do not involve these features. The NIH Office of Disease Prevention (ODP) and the NIH Office of Behavioral and Social Sciences Research (OBSSR) offer resources to make it easier for investigators to use appropriate methods to evaluate these interventions. This commentary draws attention to these issues and highlights the ODP and OBSSR resources available to investigators. We urge investigators to take advantage of these resources to learn about and adopt appropriate sample size and analytic methods for trials to evaluate behavioral interventions so that their results will be reliable and reproducible. That is the best way to advance the science of behavioral interventions to improve health.
行为干预在国立卫生研究院（NIH）支持的临床试验中被广泛应用。当行为干预涉及分组形式的组成部分和/或共享的干预人员时，它们需要特殊的设计和分析方法，而不涉及这些特征的试验则不需要这些方法。NIH疾病预防办公室（ODP）和NIH行为与社会科学研究办公室（OBSSR）提供资源，以便研究人员更容易使用适当的方法来评估这些干预措施。本评论提请人们关注这些问题，并强调ODP和OBSSR为研究人员提供的资源。我们敦促研究人员利用这些资源，了解并采用适当的样本量和分析方法来评估行为干预试验，以便其结果可靠且可重复。这是推进行为干预科学以改善健康状况的最佳途径。
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